SLAMF1

SLAMF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M27, 1KA7, 1I3Z, 1D4T, 1D4W, 1KA6
Identifiers
Aliases	SLAMF1, CD150, CDw150, SLAM, signaling lymphocytic activation molecule family member 1
External IDs	OMIM: 603492; MGI: 1351314; HomoloGene: 48162; GeneCards: SLAMF1; OMA:SLAMF1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.3 Start 160,608,106 bp End 160,647,044 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H3|1 79.54 cM Start 171,594,695 bp End 171,628,752 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus lymph node granulocyte appendix blood tonsil bone marrow cells spleen rectum pancreatic ductal cell Top expressed in blood thymus zygote secondary oocyte primary oocyte tibiofemoral joint spleen mesenteric lymph nodes embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antigen binding virus receptor activity protein binding transmembrane signaling receptor activity identical protein binding signaling receptor activity Cellular component integral component of membrane membrane plasma membrane extracellular region cell surface phagocytic vesicle extracellular exosome external side of plasma membrane Biological process adaptive immune response immune system process natural killer cell proliferation T-helper 1 cell cytokine production negative regulation of interleukin-6 production positive regulation of JNK cascade cell adhesion negative regulation of CD40 signaling pathway negative regulation of T cell cytokine production myeloid dendritic cell activation involved in immune response regulation of vesicle fusion positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade phagocytosis lymphocyte activation viral entry into host cell negative regulation of tumor necrosis factor production innate immune response regulation of catalytic activity viral process positive regulation of activated T cell proliferation negative regulation of interleukin-12 production natural killer cell differentiation signal transduction leukocyte chemotaxis involved in inflammatory response positive regulation of macrophage chemotaxis positive regulation of dendritic cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6504 27218 Ensembl ENSG00000117090 ENSMUSG00000015316 UniProt Q13291 Q9QUM4 RefSeq (mRNA) NM_003037 NM_001330754 NM_013730 NM_001360898 RefSeq (protein) NP_001317683 NP_003028 NP_038758 NP_001347827 Location (UCSC) Chr 1: 160.61 – 160.65 Mb Chr 1: 171.59 – 171.63 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene. Recently SLAMF1 has also been designated CD150 (cluster of differentiation 150).

SLAMF1 belongs to the signaling lymphocytic activation molecule family. The interaction of SLAMF1 promoter and enhancers with the Early B-cell factor 1 (EBF1) is required for the expression of SLAMF1 gene in B cells. STAT6, IRF4, and NF-kB factors involved in the transfer of the signals from the B-cell receptor, its co-receptors and IL-4R, also play important role in the regulation of SLAMF1 expression.

Interactions

SLAMF1 has been shown to interact with PTPN11, SH2D1A and SH2D1B.

Further reading

• Punnonen J, Cocks BG, Carballido JM, Bennett B, Peterson D, Aversa G, de Vries JE (1997). "Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes". J. Exp. Med. 185 (6): 993–1004. doi:10.1084/jem.185.6.993. PMC 2196230. PMID 9091591.
• Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C (1998). "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM". Nature. 395 (6701): 462–9. Bibcode:1998Natur.395..462S. doi:10.1038/26683. PMID 9774102. S2CID 4324402.
• Mikhalap SV, Shlapatska LM, Berdova AG, Law CL, Clark EA, Sidorenko SP (1999). "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis". J. Immunol. 162 (10): 5719–27. PMID 10229804.
• Li SC, Gish G, Yang D, Coffey AJ, Forman-Kay JD, Ernberg I, Kay LE, Pawson T (2000). "Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A". Curr. Biol. 9 (23): 1355–62. doi:10.1016/S0960-9822(00)80080-9. PMID 10607564.
• Rogge L, Bianchi E, Biffi M, Bono E, Chang SY, Alexander H, Santini C, Ferrari G, Sinigaglia L, Seiler M, Neeb M, Mous J, Sinigaglia F, Certa U (2000). "Transcript imaging of the development of human T helper cells using oligonucleotide arrays". Nat. Genet. 25 (1): 96–101. doi:10.1038/75671. PMID 10802665. S2CID 5449948.
• Tatsuo H, Ono N, Tanaka K, Yanagi Y (2000). "SLAM (CDw150) is a cellular receptor for measles virus". Nature. 406 (6798): 893–7. Bibcode:2000Natur.406..893T. doi:10.1038/35022579. PMID 10972291. S2CID 4409405.
• Lewis J, Eiben LJ, Nelson DL, Cohen JI, Nichols KE, Ochs HD, Notarangelo LD, Duckett CS (2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family". Clin. Immunol. 100 (1): 15–23. doi:10.1006/clim.2001.5035. PMID 11414741.
• Kruse M, Meinl E, Henning G, Kuhnt C, Berchtold S, Berger T, Schuler G, Steinkasserer A (2001). "Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta". J. Immunol. 167 (4): 1989–95. doi:10.4049/jimmunol.167.4.1989. PMID 11489980.
• Bleharski JR, Niazi KR, Sieling PA, Cheng G, Modlin RL (2001). "Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines". J. Immunol. 167 (6): 3174–81. doi:10.4049/jimmunol.167.6.3174. PMID 11544303.
• Murabayashi N, Kurita-Taniguchi M, Ayata M, Matsumoto M, Ogura H, Seya T (2002). "Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification". Microbes Infect. 4 (8): 785–94. doi:10.1016/S1286-4579(02)01598-8. PMID 12270725.
• Li C, Iosef C, Jia CY, Han VK, Li SS (2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors". J. Biol. Chem. 278 (6): 3852–9. doi:10.1074/jbc.M206649200. PMID 12458214.
• Hahm B, Arbour N, Naniche D, Homann D, Manchester M, Oldstone MB (2003). "Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule". J. Virol. 77 (6): 3505–15. doi:10.1128/JVI.77.6.3505-3515.2003. PMC 149525. PMID 12610126.
• Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057.
• Ferrand V, Li C, Romeo G, Yin L (2003). "Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients". J. Med. Virol. 70 (1): 131–6. doi:10.1002/jmv.10373. PMID 12629654. S2CID 44309832.
• Laaksonen K, Junikka M, Lahesmaa R, Terho EO, Savolainen J (2004). "In vitro allergen-induced mRNA expression of signaling lymphocytic activation molecule by PBMC of patients with allergic rhinitis is increased during specific pollen immunotherapy". J. Allergy Clin. Immunol. 112 (6): 1171–7. doi:10.1016/j.jaci.2003.08.043. PMID 14657878.

External links

• Overview of all the structural information available in the PDB for UniProt: Q13291 (Signaling lymphocytic activation molecule) at the PDBe-KB.