Clopenthixol

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by DePiep (talk | contribs) at 14:59, 29 January 2016 (Drugbox: use drug_name for title. reuse imagename, eg image caption or chemical data ('racemate') (via AWB script)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Clopenthixol
Clinical data
Routes of
administration		Oral
ATC code
Identifiers
  • (E,Z)-2-[4-[3-(2-chlorothioxanthen-9-ylidene) propyl]piperazin-1-yl]ethanol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.012.333 Edit this at Wikidata
Chemical and physical data
FormulaC22H25ClN2OS
Molar mass400.965 g/mol g·mol−1
3D model (JSmol)
  • Clc2cc1C(c3c(Sc1cc2)cccc3)=CCCN4CCN(CCO)CC4
 ☒NcheckY (what is this?)  (verify)

Clopenthixol (Sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced by Lundbeck in 1961.[1]

Clopenthixol is a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, was later introduced by Lundbeck in 1962,[2] and has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.[3]

Clopenthixol is not approved for use in the United States.

See also

References

  1. ^ Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.
  2. ^ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 516. ISBN 3-527-31058-4.{{cite book}}: CS1 maint: multiple names: authors list (link)
  3. ^ Gravem A, Engstrand E, Guleng RJ (November 1978). "Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation". Acta Psychiatr Scand. 58 (5): 384–8. doi:10.1111/j.1600-0447.1978.tb03570.x. PMID 362830.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links


Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Clopenthixol&oldid=702270612"