Parathyroid hormone 1 receptor: Difference between revisions
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Revision as of 12:25, 9 December 2008
Template:PBB Parathyroid hormone receptor 1 is a parathyroid hormone receptor It is encoded by the gene PTHR1. It is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH).
Function
It is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.[1][2]
Mechanism
It is a member of the secretin family of G protein-coupled receptors. The activity of this receptor is mediated by Gs G proteins which activate adenylyl cyclase. Besides, they also activate phosphatidylinositol-calcium second messenger system.
Pathology
Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis.[3]
See also
References
- ^ Mannstadt M, Jüppner H, Gardella TJ (1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". Am. J. Physiol. 277 (5 Pt 2): F665–75. PMID 10564229.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Mol. Endocrinol. 10 (5): 566–74. doi:10.1210/me.10.5.566. PMID 8732687.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: PTHR1 parathyroid hormone receptor 1".
Further reading
External links
- "Parathyroid Hormone Receptors: PTH1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
{{cite web}}: Cite has empty unknown parameter:|coauthors=(help) - Receptor,+Parathyroid+Hormone,+Type+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.