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Aliases ADGRA2, G protein-coupled receptor 124, TEM5, GPR124, adhesion G protein-coupled receptor A2
External IDs MGI: 1925810 HomoloGene: 13112 GeneCards: ADGRA2
RNA expression pattern
PBB GE GPR124 221814 at fs.png

PBB GE GPR124 65718 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 8: 37.78 – 37.84 Mb Chr 8: 27.09 – 27.12 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[3][4][5] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[6][7][8]


GPR124 has been shown to interact with DLG1.[9]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res. 61 (18): 6649–55. PMID 11559528. 
  4. ^ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (February 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. PMID 12565841. doi:10.1016/S0006-291X(03)00026-3. 
  5. ^ "Entrez Gene: GPR124 G protein-coupled receptor 124". 
  6. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  7. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. PMID 12435584. doi:10.1016/S0014-5793(02)03574-3. 
  8. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. PMC 3321182Freely accessible. PMID 22333914. doi:10.1038/emboj.2012.26. 
  9. ^ Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y (May 2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene. 23 (22): 3889–97. PMID 15021905. doi:10.1038/sj.onc.1207495. 

Further reading[edit]