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G protein-coupled receptor 124
Symbols GPR124 ; TEM5
External IDs OMIM606823 MGI1925810 HomoloGene13112 IUPHAR: 198 GeneCards: GPR124 Gene
RNA expression pattern
PBB GE GPR124 221814 at tn.png
PBB GE GPR124 65718 at tn.png
More reference expression data
Species Human Mouse
Entrez 25960 78560
Ensembl ENSG00000020181 ENSMUSG00000031486
UniProt Q96PE1 Q91ZV8
RefSeq (mRNA) NM_032777 NM_054044
RefSeq (protein) NP_116166 NP_473385
Location (UCSC) Chr 8:
37.64 – 37.7 Mb
Chr 8:
27.09 – 27.12 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[1][2][3] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4][5][6]


GPR124 has been shown to interact with DLG1.[7]


  1. ^ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res 61 (18): 6649–55. PMID 11559528. 
  2. ^ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (February 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841. 
  3. ^ "Entrez Gene: GPR124 G protein-coupled receptor 124". 
  4. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  5. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  6. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  7. ^ Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y (May 2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene 23 (22): 3889–97. doi:10.1038/sj.onc.1207495. PMID 15021905. 

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