LPAR1

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LPAR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLPAR1, receptor 1, lysophosphatidic acid receptor 1
External IDsMGI: 108429 HomoloGene: 1072 GeneCards: LPAR1
RNA expression pattern
PBB GE EDG2 204038 s at fs.png

PBB GE EDG2 204037 at fs.png

PBB GE EDG2 204036 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001401
NM_057159

NM_001290486
NM_010336
NM_172989

RefSeq (protein)

NP_001277415
NP_034466
NP_766577

Location (UCSC)n/aChr 4: 58.44 – 58.55 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene.[4][5][6] LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[7]

Function[edit]

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.[4]

Cancer[edit]

LPAR1 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[8] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[8]

See also[edit]

References[edit]

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038668 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ "Mouse PubMed Reference:".
  4. ^ a b "Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1".
  5. ^ Hecht JH, Weiner JA, Post SR, Chun J (November 1996). "Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex". J. Cell Biol. 135 (4): 1071–83. doi:10.1083/jcb.135.4.1071. PMC 2133395. PMID 8922387.
  6. ^ An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (February 1997). "Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 231 (3): 619–22. doi:10.1006/bbrc.1997.6150. PMID 9070858.
  7. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
  8. ^ a b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1001/jamadermatol.2018.1373. PMID 25205602.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.