LPAR3

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LPAR3
Identifiers
Aliases LPAR3, EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3, lysophosphatidic acid receptor 3
External IDs MGI: 1929469 HomoloGene: 8123 GeneCards: 23566
RNA expression pattern
PBB GE EDG7 220816 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012152

NM_022983

RefSeq (protein)

NP_036284.1

NP_075359.1

Location (UCSC) Chr 1: 84.81 – 84.89 Mb Chr 3: 146.22 – 146.29 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Lysophosphatidic acid receptor 3 also known as LPA3 is a protein that in humans is encoded by the LPAR3 gene.[1][2] LPA3 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[3]

Function[edit]

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.[1]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3". 
  2. ^ Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K (September 1999). "Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid". J. Biol. Chem. 274 (39): 27776–85. doi:10.1074/jbc.274.39.27776. PMID 10488122. 
  3. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.