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Available structures
PDB Ortholog search: PDBe RCSB
Aliases P2RY6, P2Y6, pyrimidinergic receptor P2Y6
External IDs MGI: 2673874 HomoloGene: 14289 GeneCards: P2RY6
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for P2RY6
Genomic location for P2RY6
Band 11q13.4 Start 73,264,505 bp[1]
End 73,298,617 bp[1]
RNA expression pattern
PBB GE P2RY6 208373 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 11: 73.26 – 73.3 Mb Chr 11: 100.94 – 100.97 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.[5][6]


The product of this gene, P2Y6, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.[6]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171631 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048779 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Communi D, Parmentier M, Boeynaems JM (May 1996). "Cloning, functional expression and tissue distribution of the human P2Y6 receptor". Biochemical and Biophysical Research Communications. 222 (2): 303–8. PMID 8670200. doi:10.1006/bbrc.1996.0739. 
  6. ^ a b "Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6". 

Further reading[edit]

External links[edit]

  • "P2Y Receptors: P2Y6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.