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Pyrimidinergic receptor P2Y, G-protein coupled, 6
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols P2RY6 ; P2Y6
External IDs OMIM602451 MGI2673874 HomoloGene14289 IUPHAR: 326 ChEMBL: 4714 GeneCards: P2RY6 Gene
RNA expression pattern
PBB GE P2RY6 208373 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5031 233571
Ensembl ENSG00000171631 ENSMUSG00000048779
UniProt Q15077 Q9ERK9
RefSeq (mRNA) NM_001277204 NM_183168
RefSeq (protein) NP_001264133 NP_898991
Location (UCSC) Chr 11:
73.26 – 73.3 Mb
Chr 7:
100.94 – 100.96 Mb
PubMed search [1] [2]

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.[1][2]


The product of this gene, P2Y6, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.[2]

See also[edit]


  1. ^ Communi D, Parmentier M, Boeynaems JM (May 1996). "Cloning, functional expression and tissue distribution of the human P2Y6 receptor". Biochemical and Biophysical Research Communications 222 (2): 303–8. doi:10.1006/bbrc.1996.0739. PMID 8670200. 
  2. ^ a b "Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6". 

Further reading[edit]

External links[edit]

  • "P2Y Receptors: P2Y6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.