EMR3

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Adhesion G protein-coupled receptor E3
Identifiers
Symbols ADGRE3 ; EMR3
External IDs OMIM606101 HomoloGene50009 IUPHAR: GeneCards: ADGRE3 Gene
RNA expression pattern
PBB GE EMR3 210724 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 84658 n/a
Ensembl ENSG00000131355 n/a
UniProt Q9BY15 n/a
RefSeq (mRNA) NM_001289158 n/a
RefSeq (protein) NP_001276087 n/a
Location (UCSC) Chr 19:
14.62 – 14.69 Mb
n/a
PubMed search [1] n/a

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene.[1][2] EMR3 is a member of the adhesion GPCR family.[3][4] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[5]

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.[6] Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.[7] Mice, next to Emr2, lack the Emr3 gene.[8]

Function[edit]

The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[9]

Ligands[edit]

A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.[7]

References[edit]

  1. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179. 
  2. ^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.". Pharmacological reviews 67 (2): 338–67. PMID 25713288. 
  3. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage.". Science signaling 6 (276): re3. PMID 23695165. 
  5. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  6. ^ Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J (Feb 2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes". Journal of Leukocyte Biology 81 (2): 440–8. doi:10.1189/jlb.0406276. PMID 17108056. 
  7. ^ a b Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179. 
  8. ^ Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J (Dec 2006). "An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2". FASEB Journal 20 (14): 2582–4. doi:10.1096/fj.06-6500fje. PMID 17068111. 
  9. ^ "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3". 

External links[edit]