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Cadherin, EGF LAG seven-pass G-type receptor 3
External IDs OMIM604264 MGI1858236 HomoloGene1077 IUPHAR: 180 GeneCards: CELSR3 Gene
Species Human Mouse
Entrez 1951 107934
Ensembl ENSG00000008300 ENSMUSG00000023473
UniProt Q9NYQ7 Q91ZI0
RefSeq (mRNA) NM_001407 NM_080437
RefSeq (protein) NP_001398 NP_536685
Location (UCSC) Chr 3:
48.64 – 48.66 Mb
Chr 9:
108.83 – 108.85 Mb
PubMed search [1] [2]

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.[1][2]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[2]

See also[edit]


  1. ^ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030. 
  2. ^ a b "Entrez Gene: CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.