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G protein-coupled receptor 6
Symbol GPR6
External IDs OMIM600553 MGI2155249 HomoloGene38026 IUPHAR: 85 GeneCards: GPR6 Gene
RNA expression pattern
PBB GE GPR6 214655 at tn.png
More reference expression data
Species Human Mouse
Entrez 2830 140741
Ensembl ENSG00000146360 ENSMUSG00000046922
UniProt P46095 Q6YNI2
RefSeq (mRNA) NM_001286099 NM_199058
RefSeq (protein) NP_001273028 NP_951013
Location (UCSC) Chr 6:
109.98 – 109.98 Mb
Chr 10:
41.07 – 41.07 Mb
PubMed search [1] [2]

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[1][2]


GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[3]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[4]

See also[edit]


  1. ^ "Entrez Gene: GPR6 G protein-coupled receptor 6". 
  2. ^ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049. 
  3. ^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620. 
  4. ^ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry 282 (14): 10506–15. doi:10.1074/jbc.M700911200. PMID 17284443. 

Further reading[edit]

External links[edit]

  • "GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.