GPR6

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GPR6
Identifiers
AliasesGPR6, G protein-coupled receptor 6
External IDsMGI: 2155249 HomoloGene: 38026 GeneCards: GPR6
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for GPR6
Genomic location for GPR6
Band6q21Start109,978,256 bp[1]
End109,980,718 bp[1]
RNA expression pattern
PBB GE GPR6 214655 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005284
NM_001286099

NM_199058

RefSeq (protein)

NP_001273028
NP_005275

NP_951013

Location (UCSC)Chr 6: 109.98 – 109.98 MbChr 10: 41.07 – 41.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[5][6]

Function[edit]

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[7]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146360 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046922 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: GPR6 G protein-coupled receptor 6". 
  6. ^ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049. 
  7. ^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling. 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620. 
  8. ^ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry. 282 (14): 10506–15. doi:10.1074/jbc.M700911200. PMID 17284443. 

Further reading[edit]

External links[edit]

  • "GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.