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Hydroxycarboxylic acid receptor 1
External IDs OMIM606923 MGI2441671 HomoloGene13060 IUPHAR: 311 ChEMBL: 1075101 GeneCards: HCAR1 Gene
RNA expression pattern
PBB GE GPR81 gnf1h00809 at tn.png
More reference expression data
Species Human Mouse
Entrez 27198 243270
Ensembl ENSG00000196917 ENSMUSG00000049241
UniProt Q9BXC0 Q8C131
RefSeq (mRNA) NM_032554 NM_175520
RefSeq (protein) NP_115943 NP_780729
Location (UCSC) Chr 12:
122.73 – 122.73 Mb
Chr 5:
123.88 – 123.88 Mb
PubMed search [1] [2]

G protein-coupled receptor 81, also known as GPR81, is a protein that in humans is encoded by the GPR81 gene.[1][2]

G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[1]

Lactate activates the GPR81 receptor which in turn inhibits lipolysis in fat cells.[3][4]


  1. ^ a b "Entrez Gene: GPR81 G protein-coupled receptor 81". 
  2. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  3. ^ Liu C, Wu J, Zhu J, Kuei C, Yu J, Shelton J, Sutton SW, Li X, Yun SJ, Mirzadegan T, Mazur C, Kamme F, Lovenberg TW (January 2009). "Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81". J. Biol. Chem. 284 (5): 2811–22. doi:10.1074/jbc.M806409200. PMID 19047060. 
  4. ^ Cai TQ, Ren N, Jin L, Cheng K, Kash S, Chen R, Wright SD, Taggart AK, Waters MG (December 2008). "Role of GPR81 in lactate-mediated reduction of adipose lipolysis". Biochem. Biophys. Res. Commun. 377 (3): 987–91. doi:10.1016/j.bbrc.2008.10.088. PMID 18952058. 

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