GPR183

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GPR183
Identifiers
Aliases GPR183, EBI2, G protein-coupled receptor 183
External IDs MGI: 2442034 HomoloGene: 28066 GeneCards: 1880
RNA expression pattern
PBB GE EBI2 205419 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004951

NM_183031

RefSeq (protein)

NP_004942.1

NP_898852.2

Location (UCSC) Chr 13: 99.29 – 99.31 Mb Chr 14: 121.95 – 121.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.[3]

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41.[4] This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes.[3]

EBI2 helps B cell homing within a lymph node. EBI2 expression increases during B cell activation, after B cell receptor and CD40 stimulation; its expression decreases during germinal cell development due to BCL6--a transcription factor required in germinal center development. EBI2 must turn off to move B cells to the germinal center from the periphery, and must turn on for B cells to exit the germinal center and re-enter the periphery.[5] EBI2 is a receptor for oxysterols, the most potent activator being 7α,25-dihydroxycholesterol.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: EBI2 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)". 
  4. ^ Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (Apr 1993). "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors". J Virol. 67 (4): 2209–20. PMC 240341free to read. PMID 8383238. 
  5. ^ Pereira JP, Kelly LM, Xu Y, Cyster JG (Aug 2009). "EBI2 mediates B cell segregation between the outer and centre follicle". Nature. 460 (7259): 1122–6. doi:10.1038/nature08226. PMID 19597478. 
  6. ^ Liu C, Yang X, Wu J, Kuei C, Mani N, Zhang L, Yu J, Sutton S, Qin N, Banie H, Karlsson L, Sun S, Lovenberg T (Jul 2011). "Oxysterols direct immune cell migration via EBI2". Nature. 475 (7357): 519–23. doi:10.1038/nature10226. PMID 2179621. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.