Bombesin-like receptor 3

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Aliases BRS3, BB3, bombesin like receptor 3, BB3R, bombesin receptor subtype 3
External IDs OMIM: 300107 MGI: 1100501 HomoloGene: 1307 GeneCards: BRS3
RNA expression pattern
PBB GE BRS3 207369 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr X: 136.49 – 136.49 Mb Chr X: 57.04 – 57.05 Mb
PubMed search [1] [2]
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The bombesin receptor subtype 3 also known as BRS-3 or BB3[3] is a protein which in humans is encoded by the BRS3 gene.[4][5]


Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[5][6]

BB3 is a G protein-coupled receptor.[4] BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[4][7][8]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  4. ^ a b c Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. 
  5. ^ a b Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1-2): 165–72. doi:10.1016/S0006-8993(97)00380-6. PMID 9262170. 
  6. ^ "Entrez Gene: BRS3 bombesin-like receptor 3". 
  7. ^ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH & Jensen RT (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors.". J. Biol. Chem. 272 (41): 26062–26071. doi:10.1074/jbc.272.41.26062. PMID 9325344. 
  8. ^ Jensen RT, Battey JF, Spindel ER & Benya RV (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states.". Pharmacol. Rev. 60 (1): 1–42. doi:10.1124/pr.107.07108. PMC 2517428Freely accessible. PMID 18055507. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.