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Adhesion G protein-coupled receptor F1
Symbols ADGRF1 ; GPR110; KPG_012; PGR19; hGPCR36
External IDs MGI1924846 HomoloGene124643 IUPHAR: GeneCards: ADGRF1 Gene
RNA expression pattern
PBB GE GPR110 220907 at tn.png
More reference expression data
Species Human Mouse
Entrez 266977 77596
Ensembl ENSG00000153292 ENSMUSG00000041293
UniProt Q5T601 Q8VEC3
RefSeq (mRNA) NM_025048 NM_133776
RefSeq (protein) NP_079324 NP_598537
Location (UCSC) Chr 6:
47 – 47.04 Mb
Chr 17:
43.27 – 43.32 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene.[1][2] This gene encodes a member of the adhesion-GPCR receptor family.[3] Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4]


  1. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  2. ^ "Entrez Gene: GPR110 G protein-coupled receptor 110". 
  3. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 

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