Neuropeptide Y receptor Y2

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NPY2R
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNPY2R, NPY2-R, Neuropeptide Y receptor Y2
External IDsMGI: 108418 HomoloGene: 701 GeneCards: NPY2R
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for NPY2R
Genomic location for NPY2R
Band4q32.1Start155,208,636 bp[1]
End155,217,078 bp[1]
RNA expression pattern
PBB GE NPY2R 210730 s at fs.png

PBB GE NPY2R 210729 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000910
NM_001370180

NM_001205099
NM_008731

RefSeq (protein)

NP_000901
NP_001357109

NP_001192028
NP_032757

Location (UCSC)Chr 4: 155.21 – 155.22 MbChr 3: 82.54 – 82.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.[5][6]

Selective ligands[edit]

Agonists[edit]

  • Neuropeptide Y (endogenous agonist, non subtype selective)
  • Neuropeptide Y fragment 13-36 (NPY2 selective agonist)
  • Peptide YY
  • Peptide YY 3-36 fragment[7]

Antagonists[edit]

  • BIIE-0246 (CAS# 246146-55-4)
  • JNJ 5207787 (CAS# 683746-68-1)
  • SF 11 (CAS# 443292-81-7)

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185149 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028004 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Sep 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.
  6. ^ "Entrez Gene: NPY2R neuropeptide Y receptor Y2".
  7. ^ Murphy KG, Dhillo WS, Bloom SR (Dec 2006). "Gut peptides in the regulation of food intake and energy homeostasis". Endocrine Reviews. 27 (7): 719–27. doi:10.1210/er.2006-0028. PMID 17077190.

External links[edit]

Further reading[edit]