Prostaglandin EP3 receptor

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Aliases PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R, EP3-VI, Prostaglandin E receptor 3
External IDs MGI: 97795 HomoloGene: 105703 GeneCards: 5733
RNA expression pattern
PBB GE PTGER3 210374 x at tn.png

PBB GE PTGER3 210375 at tn.png

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More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 1: 70.85 – 71.05 Mb Chr 3: 157.57 – 157.65 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Prostaglandin E2 receptor 3 (EP3) is a prostaglandin receptor, encoded by the PTGER3 gene.[1]


The receptor is a member of the G-protein coupled receptor family. It works through the G protein Gi, leading to a decrease in cytosolic cyclic AMP (cAMP). It is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions.

Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.


Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.[1]

See also[edit]


External links[edit]

  • "Prostanoid Receptors: EP3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.