Prostaglandin EP3 receptor

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Prostaglandin E receptor 3 (subtype EP3)
Symbols PTGER3 ; EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; EP3e; PGE2-R
External IDs OMIM176806 MGI97795 HomoloGene105703 IUPHAR: 342 ChEMBL: 3710 GeneCards: PTGER3 Gene
RNA expression pattern
PBB GE PTGER3 210375 at tn.png
PBB GE PTGER3 210374 x at tn.png
PBB GE PTGER3 210831 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5733 19218
Ensembl ENSG00000050628 ENSMUSG00000040016
UniProt P43115 Q6PDF2
RefSeq (mRNA) NM_000957 NM_011196
RefSeq (protein) NP_001119516 NP_035326
Location (UCSC) Chr 1:
70.85 – 71.05 Mb
Chr 3:
157.57 – 157.65 Mb
PubMed search [1] [2]

Prostaglandin E2 receptor 3 (EP3) is a prostaglandin receptor, encoded by the PTGER3 gene.[1]


The receptor is a member of the G-protein coupled receptor family. It works through the G protein Gi, leading to a decrease in cytosolic cyclic AMP (cAMP). It is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions.

Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.


Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.[1]

See also[edit]


External links[edit]

  • "Prostanoid Receptors: EP3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.