Neuropeptides B/W receptor 1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NPBWR1
Identifiers
Aliases NPBWR1, GPR7, Neuropeptides B/W receptor 1
External IDs MGI: 891989 HomoloGene: 21096 GeneCards: 2831
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005285

NM_010342

RefSeq (protein)

NP_005276.2

NP_034472.1

Location (UCSC) Chr 8: 52.94 – 52.94 Mb Chr 1: 5.91 – 5.92 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neuropeptides B/W receptor 1, also known as NPBW1 and GPR7, is a human protein encoded by the NPBWR1 gene.[1] As implied by its name, it and related gene NPBWR2 (with which it shares 70% nucleotide identity) are transmembranes protein that bind Neuropeptide B (NPB) and Neuropeptide W (NPW), both proteins expressed strongly in parts of the brain that regulate stress and fear including the extended amygdala and stria terminalis. When originally discovered in 1995, these receptors had no known ligands ("orphan receptors") and were called GPR7 and GPR8,[2] but at least three groups in the early 2000s independently identified their endogenous ligands, triggering the name change in 2005.[3]

Structure[edit]

NPBW1 has seven transmembrane domains, which it unsurprisingly shares with NPBW2, but also a family of somatostatin and opioid receptors,[4] and like these proteins couple to Gi-class G proteins.[5]

Functions[edit]

In rodent models, NPBWR1 is over-expressed in Schwann cells associated with neuropathic pain, suggesting it inhibits inflammatory pain responses.[6] Mice without NPBW1 exhibited a stronger hostile reaction to intruders, suggesting NPBW1 has a role in stress responses.[7] Early studies indicated that NPB and NPW had a complex effect on appetite, but generally led to anorexia.[8] Similarly, male rats lacking NPBWR1 exhibited hyperphagia and adult-onset obesity, though why female rats are unaffected is unknown.[9] Researchers speculated that activating these pathways might decrease obesity, and synthesized a small-molecule ligand that is capable of stimulating both receptors at low concentrations.[10]


References[edit]

  1. ^ "Entrez Gene: NPBWR1 neuropeptides B/W receptor 1". 
  2. ^ O’Dowd B. F., Scheideler M. A., Nguyen T., Cheng R., Rasmussen J. S., Marchese A., et al. (1995). The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. Genomics 28, 84–91. doi:10.1006/geno.1995.1109
  3. ^ Davenport A., Singh G. (2005). Neuropeptide W/Neuropeptide B Receptors – NPBW1. IUPHAR Receptor database. doi:10.1786/080844542445
  4. ^ Hondo M., Ishii M., Sakurai T. (2008). The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion. Results Probl. Cell Differ. 46, 239–256. doi:10.1007/400_2007_056
  5. ^ Tanaka H., Yoshida T., Miyamoto N., Motoike T., Kurosu H., Shibata K., et al. (2003). Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc. Natl. Acad. Sci. U.S.A. 100, 6251–6256. doi:10.1073/pnas.2233339100
  6. ^ Zaratin P., Quattrini A., Previtali S., Comi G., Hervieu G., Scheideler M. (2005). Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies. Mol. Cell. Neurosci. 28, 55–63 doi:10.1016/j.mcn.2004.08.010
  7. ^ Nagata-Kuroiwa R., Furutani N., Hara J., Hondo M., Ishii M., Abe T., et al. (2011). Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory. PLoS ONE 6:e16972. doi:10.1371/journal.pone.0016972
  8. ^ Tanaka H., Yoshida T., Miyamoto N., Motoike T., Kurosu H., Shibata K., et al. (2003). Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc. Natl. Acad. Sci. U.S.A. 100, 6251–6256. doi:10.1073/pnas.2233339100
  9. ^ Ishii M., Fei H., Friedman J. M. (2003). Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc. Natl. Acad. Sci. U.S.A. 100, 10540–10545, doi:10.1073/pnas.1334189100
  10. ^ Romero F. A., Hastings N. B., Moningka R., Guo Z., Wang M., Di Salvo J., et al. (2012). The discovery of potent antagonists of NPBWR1 (GPR7). Bioorg. Med. Chem. Lett. 22, 1014–1018. doi:10.1016/j.bmcl.2011.11.126

External links[edit]

Further reading[edit]