Niacin receptor 2

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Aliases HCAR3, GPR109B, HCA3, HM74, PUMAG, Puma-g, Niacin receptor 2, hydroxycarboxylic acid receptor 3
External IDs HomoloGene: 130547 GeneCards: HCAR3
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for HCAR3
Genomic location for HCAR3
Band No data available Start 122,714,756 bp[1]
End 122,716,892 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 12: 122.71 – 122.72 Mb n/a
PubMed search [2] n/a
View/Edit Human

Niacin receptor 2 (NIACR2), also known as hydroxycarboxylic acid receptor 3 (HCA3 or HCAR3) and GPR109B, is a protein which in humans is encoded by the HCAR3 gene.[3][4]


GPR109B is a low affinity receptor for nicotinic acid (niacin)[5] and is a member of the nicotinic acid receptor family of G protein-coupled receptors (the other identified member being GPR109A).

GPR109B is a Gi/Go-coupled G protein-coupled receptor with low affinity for nicotinic acid.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000255398 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ "Entrez Gene: GPR109B G protein-coupled receptor 109B". 
  4. ^ Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology. 5 (10): 1239–49. PMID 7505609. doi:10.1093/intimm/5.10.1239. 
  5. ^ a b Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB (March 2003). "Molecular identification of high and low affinity receptors for nicotinic acid". The Journal of Biological Chemistry. 278 (11): 9869–74. PMID 12522134. doi:10.1074/jbc.M210695200. 

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