Brain-specific angiogenesis inhibitor 3

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Available structures
PDB Ortholog search: PDBe RCSB
Aliases ADGRB3, BAI3, adhesion G protein-coupled receptor B3
External IDs MGI: 2441837 HomoloGene: 1289 GeneCards: ADGRB3
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 68.64 – 69.39 Mb Chr 1: 25.07 – 25.83 Mb
PubMed search [1] [2]
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Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.[3][4]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[4]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.[5] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1-2): 103–8. doi:10.1159/000134693. PMID 9533023. 
  4. ^ a b "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3". 
  5. ^ Marc F. Bolliger, David C. Martinelli, and Thomas C. Südhof. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. PNAS 2011 ; published ahead of print January 24, 2011, doi:10.1073/pnas.1019577108

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.