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G protein-coupled receptor 35
Symbol GPR35
External IDs OMIM602646 MGI1929509 HomoloGene3874 IUPHAR: 102 ChEMBL: 1293267 GeneCards: GPR35 Gene
RNA expression pattern
PBB GE GPR35 210264 at tn.png
More reference expression data
Species Human Mouse
Entrez 2859 64095
Ensembl ENSG00000178623 ENSMUSG00000026271
UniProt Q9HC97 Q9ES90
RefSeq (mRNA) NM_001195381 NM_001104529
RefSeq (protein) NP_001182310 NP_001097999
Location (UCSC) Chr 2:
240.61 – 240.63 Mb
Chr 1:
92.95 – 92.99 Mb
PubMed search [1] [2]

G protein-coupled receptor 35 also known as GPR35 is a G protein-coupled receptor which in humans is encoded by the GPR35 gene.[1] Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.



Selective agonists of GPR35 include:


Antagonists of GPR35 include:

  • ML145 (CID-2286812)[5]
  • ML144 (CID-1542103)[5]

Clinical significance[edit]

Deletion of GPR35 gene may be responsible for brachydactyly mental retardation syndrome and is mutated in 2q37 monosomy and 2q37 deletion syndrome.[6] In one study GPR35 has been recognised as a potential oncogene in stomach cancer.[7]


  1. ^ O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR (1998). "Discovery of three novel G-protein-coupled receptor genes". Genomics 47 (2): 310–3. doi:10.1006/geno.1998.5095. PMID 9479505. 
  2. ^ a b c d e Zhao, Pingwei; Sharir, Haleli; Kapur, Ankur; Cowan, Alan; Geller, Ellen B; Adler, Martin W; Seltzman, Herbert H; Reggio, Patricia H; Heynen-Genel, Susanne; Sauer, Michelle; Chung, Thomas D Y; Bai, Yushi; Chen, Wei; Caron, Marc G; Barak, Larry S; Abood, Mary E; (2010). "Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.". Molecular Pharmacology 78 (4). doi:10.1124/mol.110.066746. PMC 2981393. PMID 20826425. 
  3. ^ Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, Tian H, Ling L (2006). "Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35". J. Biol. Chem. 281 (31): 22021–8. doi:10.1074/jbc.M603503200. PMID 16754668. free fulltext
  4. ^ Taniguchi Y, Tonai-Kachi H, Shinjo K (2006). "Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35". FEBS Lett. 580 (21): 5003–8. doi:10.1016/j.febslet.2006.08.015. PMID 16934253. 
  5. ^ a b Susanne Heynen-Genel, Russell Dahl, Shenghua Shi, Michelle Sauer, Santosh Hariharan, Eduard Sergienko, Shakeela Dad, Thomas DY Chung, Derek Stonich, Ying Su, Marc Caron, Pingwei Zhao, Mary E Abood, and Lawrence S Barak (2010). "Selective GPR35 Antagonists - Probes 1 & 2". PMID 21433393. Bookshelf ID NBK50703. 
  6. ^ Shrimpton AE, Braddock BR, Thomson LL, Stein CK, Hoo JJ (2004). "Molecular delineation of deletions on 2q37.3 in three cases with an Albright hereditary osteodystrophy-like phenotype". Clin. Genet. 66 (6): 537–44. doi:10.1111/j.1399-0004.2004.00363.x. PMID 15521982. 
  7. ^ Okumura S, Baba H, Kumada T, Nanmoku K, Nakajima H, Nakane Y, Hioki K, Ikenaka K (2004). "Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells". Cancer Sci. 95 (2): 131–5. doi:10.1111/j.1349-7006.2004.tb03193.x. PMID 14965362.