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Adhesion G protein-coupled receptor D1
Symbols ADGRD1 ; GPR133; PGR25
External IDs OMIM613639 MGI3041203 HomoloGene34616 IUPHAR: GeneCards: ADGRD1 Gene
Species Human Mouse
Entrez 283383 243277
Ensembl ENSG00000111452 ENSMUSG00000044017
UniProt Q6QNK2 Q80T32
RefSeq (mRNA) NM_198827 NM_001081342
RefSeq (protein) NP_942122 NP_001074811
Location (UCSC) Chr 12:
130.95 – 131.14 Mb
Chr 5:
129.1 – 129.2 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.[1][2]

This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3][4]


  1. ^ "Entrez Gene: GPR133 G protein-coupled receptor 133". 
  2. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  3. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 

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