Pyroglutamylated RFamide peptide receptor: Difference between revisions
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'''G protein-coupled receptor 103''', also known as '''GPR103''', is a [[protein]] which in humans is encoded by the ''GPR103'' [[gene]].<ref name="entrez"/><ref name="pmid11574155">{{cite journal | author = Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF | title = Discovery and mapping of ten novel G protein-coupled receptor genes | journal = Gene | volume = 275 | issue = 1 | pages = 83–91 | year = 2001 | month = September | pmid = 11574155 | doi = 10.1016/S0378-1119(01)00651-5 | url = | issn = }}</ref> |
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'''G protein-coupled receptor 103''', also known as '''GPR103''', is a human [[gene]].<ref name="entrez"/> |
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==Function== |
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| ⚫ | [[G protein-coupled receptor]]s (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric [[G protein]]s.<ref name="entrez">{{cite web | title = Entrez Gene: GPR103 G protein-coupled receptor 103| url =http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84109| accessdate = }}</ref> |
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A 26-amino acid RF-amide peptide, [[QRFP|P518]] functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.<ref name="pmid12714592">{{cite journal | author = Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL | title = Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155 | journal = J. Biol. Chem. | volume = 278 | issue = 30 | pages = 27652–7 | year = 2003 | month = July | pmid = 12714592 | doi = 10.1074/jbc.M302945200 | url = | issn = }}</ref> The 43-amino acid [[QRFP]] peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of [[aldosterone]], suggesting that QRFP and GPR103 regulate [[adrenal]] function.<ref name="pmid12960173">{{cite journal | author = Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M | title = A new peptidic ligand and its receptor regulating adrenal function in rats | journal = J. Biol. Chem. | volume = 278 | issue = 47 | pages = 46387–95 | year = 2003 | month = November | pmid = 12960173 | doi = 10.1074/jbc.M305270200 | url = | issn = }}</ref> |
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==References== |
==References== |
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==Further reading== |
==Further reading== |
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==External links== |
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*{{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1347 | title = Peptide P518 Receptor | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }} |
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Revision as of 22:18, 9 December 2008
Template:PBB G protein-coupled receptor 103, also known as GPR103, is a protein which in humans is encoded by the GPR103 gene.[1][2]
Function
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[1]
A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[3] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.[4]
References
- ^ a b "Entrez Gene: GPR103 G protein-coupled receptor 103".
- ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
Further reading
External links
- "Peptide P518 Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
{{cite web}}: Cite has empty unknown parameter:|coauthors=(help)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.