EMR1
Template:PBB EGF-like module-containing mucin-like hormone receptor-like 1 is a protein that in humans is encoded by the EMR1 gene.[1][2][3] The mouse homologue is known as F4/80.[4]
Function
This gene encodes a protein that is a member of the adhesion-GPCR family [5] . Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a mucin-like spacer region. In the case of EMR1 these domains are Epidermal Growth Factor ([[EGF-like] domains.
Emr1 is a transmembrane protein present on the cell-surface of human macrophages, which are derived from the myeloid lineage. It has an approximate mass of 125 kDa, and is associated with mature macrophages.
See also
References
- ^ Baud V, Chissoe SL, Viegas-Pequignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ McKnight AJ, Gordon S (1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". J Leukoc Biol. 63 (3): 271–80. PMID 9500513.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".
- ^ Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (1994). "Markers of mouse macrophage development detected by monoclonal antibodies". J. Immunol. Methods. 174 (1–2): 5–19. PMID 8083537.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Yona, Stacey (2011). Adhesion-GPCRs. Springer. pp. 1–200. ISBN 978-1-4419-7912-4.
Further reading
- McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S (1998). "Chromosome mapping of the Emr1 gene". Mamm. Genome. 8 (12): 946. doi:10.1007/s003359900633. PMID 9383301.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Carver EA, Hamann J, Olsen AS, Stubbs L (2000). "Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication". Mamm. Genome. 10 (10): 1039–40. doi:10.1007/s003359901157. PMID 10501980.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Lin HH, Stacey M, Hamann J; et al. (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics. 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
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