CD200

For other uses, see CD200 (disambiguation).

CD200
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BFI
Identifiers
Aliases	CD200, CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-200
External IDs	OMIM: 155970; MGI: 1196990; HomoloGene: 4344; GeneCards: CD200; OMA:CD200 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q13.2 Start 112,332,347 bp End 112,362,812 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 B5|16 29.53 cM Start 45,202,498 bp End 45,229,416 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole ganglionic eminence Brodmann area 10 middle frontal gyrus hypothalamus orbitofrontal cortex Brodmann area 9 parietal pleura Brodmann area 46 Brodmann area 23 Top expressed in ascending aorta ventral tegmental area dorsomedial hypothalamic nucleus ventromedial nucleus paraventricular nucleus of hypothalamus suprachiasmatic nucleus body of femur arcuate nucleus aortic valve median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding protein binding protein homodimerization activity cell adhesion molecule binding protein binding involved in heterotypic cell-cell adhesion glycosylated region protein binding Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane cell surface axon neuron projection neuronal cell body cell body Biological process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell recognition homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of macrophage activation regulation of immune response negative regulation of leukocyte activation negative regulation of cell population proliferation negative regulation of NF-kappaB transcription factor activity positive regulation of CREB transcription factor activity heterotypic cell-cell adhesion positive regulation of transforming growth factor beta production cell-cell adhesion positive regulation of arginase activity positive regulation of protein-glutamine gamma-glutamyltransferase activity regulation of neuroinflammatory response negative regulation of neuroinflammatory response negative regulation of neuron death negative regulation of matrix metallopeptidase secretion negative regulation of macrophage migration negative regulation of T cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4345 17470 Ensembl ENSG00000091972 ENSMUSG00000022661 UniProt P41217 O54901 RefSeq (mRNA) NM_001004196 NM_001004197 NM_005944 NM_001318826 NM_001318828 NM_001318830 NM_001365851 NM_001365852 NM_001365853 NM_001365854 NM_001365855 NM_010818 NM_001358443 RefSeq (protein) NP_001004196 NP_001305755 NP_001305757 NP_001305759 NP_005935 NP_001352780 NP_001352781 NP_001352782 NP_001352783 NP_001352784 n/a Location (UCSC) Chr 3: 112.33 – 112.36 Mb Chr 16: 45.2 – 45.23 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200) is a human protein encoded by the CD200 gene.

The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.

See also

• Cluster of differentiation

Further reading

• Gorczynski RM (2002). "Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth". Arch. Immunol. Ther. Exp. (Warsz.). 49 (4): 303–9. PMID 11726033.
• Douglas J, Albertson DG, Barclay AN, et al. (1988). "RFLP and mapping of human MOX-1 gene on chromosome 3". Nucleic Acids Res. 16 (18): 9067. doi:10.1093/nar/16.18.9067. PMC 338677. PMID 2902568.
• McCaughan GW, Clark MJ, Barclay AN (1987). "Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein". Immunogenetics. 25 (5): 329–35. doi:10.1007/BF00404426. PMID 3032785. S2CID 500342.
• Wright GJ, Puklavec MJ, Willis AC, et al. (2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.
• Hoek RM, Ruuls SR, Murphy CA, et al. (2000). "Down-regulation of the macrophage lineage through interaction with OX2 (CD200)". Science. 290 (5497): 1768–71. Bibcode:2000Sci...290.1768H. doi:10.1126/science.290.5497.1768. PMID 11099416.
• Wright GJ, Jones M, Puklavec MJ, et al. (2001). "The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans". Immunology. 102 (2): 173–9. doi:10.1046/j.1365-2567.2001.01163.x. PMC 1783166. PMID 11260322.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wright GJ, Cherwinski H, Foster-Cuevas M, et al. (2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200". J. Immunol. 171 (6): 3034–46. doi:10.4049/jimmunol.171.6.3034. PMID 12960329.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chen DX, Gorczynski RM (2005). "Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function". Transplantation. 79 (3): 282–8. doi:10.1097/01.TP.0000149506.61000.86. PMID 15699757. S2CID 19242441.
• Chen Z, Marsden PA, Gorczynski RM (2006). "Cloning and characterization of the human CD200 promoter region". Mol. Immunol. 43 (6): 579–87. doi:10.1016/j.molimm.2005.04.014. hdl:1807/16344. PMID 15955564.
• Shiratori I, Yamaguchi M, Suzukawa M, et al. (2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". J. Immunol. 175 (7): 4441–9. doi:10.4049/jimmunol.175.7.4441. PMID 16177086.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Matsue H (2006). "CD 200-mediated regulation of skin immunity". J. Invest. Dermatol. 125 (6): x–xi. doi:10.1111/j.0022-202X.2005.23978.x. PMID 16354172.

External links

• CD200+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD200 genome location and CD200 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: O54901 (Mouse OX-2 membrane glycoprotein (CD200)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.