GPR32

GPR32
Identifiers
Aliases	GPR32, RVDR1, G protein-coupled receptor 32
External IDs	OMIM: 603195 HomoloGene: 88647 GeneCards: GPR32
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,771,732 bp
RNA expression pattern
	Top expressed in
	placenta; ; tibialis anterior muscle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; complement receptor activity; N-formyl peptide receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; complement receptor mediated signaling pathway; inflammatory response; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; leukocyte migration; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	2854
	n/a
	ENSG00000142511
	n/a
	O75388
	n/a
	NM_001506
	n/a
	NP_001497
	n/a
	Wikidata
View/Edit Human

G protein-coupled receptor 32, also known as GPR32 or the RvD1 receptor, is a human gene belonging to the rhodopsin-like subfamily of G protein-coupled receptors.^[3] GPR32 is most closely related to the chemotaxic formyl peptide receptors.^[4]

At least 5 members of the D series of resolvins (RvDs) viz., RvD1, AT-RVD1, RvD3, AT-RvD3, and RvD5, activate their target cells through this receptor; these results have led to naming GPR32 the RVD1 receptor (see Resolvin#Mechanisms of Action).^[5]^[6]^[7] RvDs are members of the specialized proresolving mediators (SPM) class of polyunsaturated fatty acid metabolites. RVDs are metabolites of the omega-3 fatty acid, docosahexaenoic acid (DHA), and, along with other SRMs contribute to the inhibition and resolution of a diverse range of inflammation and inflammation-related responses as well as to the healing of these inflammatory lesions in animals and humans.^[8] The metabolism of DHA to RVD's and the activation of GPR32 by these RVD's are proposed to be one mechanism by which omega-3 fatty acids may ameliorate inflammation as well as various inflammation-based and other diseases.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142511 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR32 G protein-coupled receptor 32".
^ Marchese A, Nguyen T, Malik P, Xu S, Cheng R, Xie Z, Heng HH, George SR, Kolakowski LF, O'Dowd BF (June 1998). "Cloning genes encoding receptors related to chemoattractant receptors". Genomics. 50 (2): 281–6. doi:10.1006/geno.1998.5297. PMID 9653656.
^ Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH, Yang R, Petasis NA, Serhan CN (January 2010). "Resolvin D1 binds human phagocytes with evidence for proresolving receptors". Proceedings of the National Academy of Sciences of the United States of America. 107 (4): 1660–5. doi:10.1073/pnas.0907342107. PMC 2824371. PMID 20080636.
^ Serhan CN, Chiang N, Dalli J, Levy BD (February 2015). "Lipid mediators in the resolution of inflammation". Cold Spring Harbor Perspectives in Biology. 7 (2): a016311. doi:10.1101/cshperspect.a016311. PMID 25359497.
^ Orr SK, Colas RA, Dalli J, Chiang N, Serhan CN (May 2015). "Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent". American Journal of Physiology. Lung Cellular and Molecular Physiology. 308 (9): L904-11. doi:10.1152/ajplung.00370.2014. PMC 4421783. PMID 25770181.
^ Headland SE, Norling LV (May 2015). "The resolution of inflammation: Principles and challenges". Seminars in Immunology. 27 (3): 149–60. doi:10.1016/j.smim.2015.03.014. PMID 25911383.
^ Calder PC (April 2015). "Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance". Biochimica et Biophysica Acta. 1851 (4): 469–84. doi:10.1016/j.bbalip.2014.08.010. PMID 25149823.

References

Further reading