Prostaglandin F receptor: Difference between revisions
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==References== |
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==External links== |
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*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2424 | title = Prostanoid Receptors: FP | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }} |
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==Further reading== |
==Further reading== |
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Revision as of 15:11, 9 December 2008
Template:PBB Prostaglandin F receptor (FP) is a receptor for Prostaglandin F2α. It is encoded by the gene PTGFR.[1]
It is a member of the G-protein coupled receptor family.
Two transcript variants encoding different isoforms have been found for this gene.[1]
Functions
Main effects of prostaglandin binding to the receptor are:
- uterine contraction
- bronchoconstriction[2]
Via activation of this receptor, PGF2-alpha mediates luteolysis[1], and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters[3].
Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.[4]
See also
References
- ^ a b c "Entrez Gene: PTGFR prostaglandin F receptor (FP)".
- ^ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 234
- ^ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
- ^ Sugimoto Y, Yamasaki A, Segi E; et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science. 277 (5326): 681–3. PMID 9235889.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
External links
- "Prostanoid Receptors: FP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
{{cite web}}: Cite has empty unknown parameter:|coauthors=(help)
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.