From Wikipedia, the free encyclopedia
G protein-coupled receptor 6 , also known as GPR6 , is a protein which in humans is encoded by the GPR6 gene .[5] [6]
Function
GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors . It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate .[7]
GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[8]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000146360 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046922 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: GPR6 G protein-coupled receptor 6" .
^ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors" . Genomics . 28 (2): 347–9. doi :10.1006/geno.1995.1154 . PMID 8530049 .
^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling . 14 (11): 941–53. doi :10.1016/S0898-6568(02)00041-4 . PMID 12220620 .
^ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth" . The Journal of Biological Chemistry . 282 (14): 10506–15. doi :10.1074/jbc.M700911200 . PMID 17284443 .
Further reading
Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol . 14 (1): 25–35. doi :10.1089/dna.1995.14.25 . PMID 7832990 .
Song ZH, Modi W, Bonner TI (1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors" . Genomics . 28 (2): 347–9. doi :10.1006/geno.1995.1154 . PMID 8530049 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Uhlenbrock K, Huber J, Ardati A, et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cell. Physiol. Biochem . 13 (2): 75–84. doi :10.1159/000070251 . PMID 12649592 .
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. doi :10.1038/nature02055 . PMID 14574404 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
External links
"GPR6" . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology.