GPR12

GPR12
Identifiers
Aliases	GPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDs	OMIM: 600752 MGI: 101909 HomoloGene: 3868 GeneCards: GPR12
Gene location (Human)
Chr.	Chromosome 13 (human)
End	26,760,786 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	146,522,049 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellar hemisphere; ; nucleus accumbens; ; caudate nucleus; ; prefrontal cortex; ; putamen; ; Brodmann area 9; ; cingulate gyrus; ; pancreatic ductal cell; ; tibialis anterior muscle;
	Top expressed in
	entorhinal cortex; ; superior frontal gyrus; ; hippocampus proper; ; Region I of hippocampus proper; ; caudate nucleus; ; secondary oocyte; ; medial dorsal nucleus; ; nucleus accumbens; ; barrel cortex; ; amygdala;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; phosphatidylcholine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; cellular calcium ion homeostasis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2835
	14738
	ENSG00000132975
	ENSMUSG00000041468
	P47775
	P35412
	NM_005288
NM_001010941; NM_008151; NM_001359055; NM_001359056; NM_001359057;
	NM_001359058
	NP_005279
NP_001010941; NP_032177; NP_001345984; NP_001345985; NP_001345986;
	NP_001345987
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.^[5]^[6]^[7]

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132975 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041468 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (Jan 1994). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Lett. 336 (2): 317–322. doi:10.1016/0014-5793(93)80828-I. PMID 8262253.
^ Song ZH, Modi W, Bonner TI (Feb 1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.
^ "Entrez Gene: GPR12 G protein-coupled receptor 12".
^ Bjursell, Mikael; Gerdin, Anna-Karin; Jönsson, Marie; Surve, Vikas V.; Svensson, Lennart; Huang, Xu-Feng; Törnell, Jan; Bohlooly-Y, Mohammad (2006-09-22). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–366. doi:10.1016/j.bbrc.2006.07.090. ISSN 0006-291X. PMID 16887097.

Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Uhlenbrock K; Huber J; Ardati A; et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cell. Physiol. Biochem. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Dunham A; Matthews LH; Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–528. doi:10.1038/nature02379. PMC 2665288. PMID 15057823. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132975 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041468 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8262253-5] Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (Jan 1994). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Lett. 336 (2): 317–322. doi:10.1016/0014-5793(93)80828-I. PMID 8262253.

[pmid8530049-6] Song ZH, Modi W, Bonner TI (Feb 1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.

[entrez-7] "Entrez Gene: GPR12 G protein-coupled receptor 12".

[8] Bjursell, Mikael; Gerdin, Anna-Karin; Jönsson, Marie; Surve, Vikas V.; Svensson, Lennart; Huang, Xu-Feng; Törnell, Jan; Bohlooly-Y, Mohammad (2006-09-22). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–366. doi:10.1016/j.bbrc.2006.07.090. ISSN 0006-291X. PMID 16887097.

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References

Further reading