C5AR2

C5AR2
Identifiers
Aliases	C5AR2, C5L2, GPR77, complement component 5a receptor 2, complement C5a receptor 2, C5a2
External IDs	OMIM: 609949 MGI: 2442013 HomoloGene: 49549 GeneCards: C5AR2
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 47,332,175 bp End 47,347,329 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A2 Start 15,968,510 bp End 15,978,079 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood spleen right lung upper lobe of left lung gastric mucosa bone marrow cells left uterine tube right coronary artery appendix Top expressed in yolk sac placenta secondary oocyte liver bone marrow jejunum esophagus ileum heart spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signal transducer activity complement component C5a receptor activity G protein-coupled receptor activity Cellular component integral component of membrane plasma membrane basal plasma membrane apical part of cell membrane integral component of plasma membrane Biological process negative regulation of neutrophil chemotaxis chemotaxis G protein-coupled receptor signaling pathway negative regulation of tumor necrosis factor production signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of epithelial cell proliferation regulation of complement activation inflammatory response phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration complement component C5a signaling pathway complement receptor mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27202 319430 Ensembl ENSG00000134830 ENSMUSG00000074361 UniProt Q9P296 Q8BW93 RefSeq (mRNA) NM_001271749 NM_001271750 NM_018485 NM_001146005 NM_176912 RefSeq (protein) NP_001258678 NP_001258679 NP_060955 NP_001139477 NP_795886 Location (UCSC) Chr 19: 47.33 – 47.35 Mb Chr 7: 15.97 – 15.98 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

C5a anaphylatoxin chemotactic receptor C5a2 also known as C5L2, G protein-coupled receptor 77, is a protein that in humans is encoded by the C5AR2 gene.

Function

The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5a2 is coexpressed with the C5a receptor, (C5a1, C5aR, C5R1, CD88), on polymorphonuclear neutrophils and may modulate C5a1 activity.

Further reading

• Klos A, Wende E, Wareham KJ, Monk PN (2013). "International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacol. Rev. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.
• Ohno M, Hirata T, Enomoto M, et al. (2000). "A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells". Mol. Immunol. 37 (8): 407–12. doi:10.1016/S0161-5890(00)00067-5. PMID 11090875.
• Cain SA, Monk PN (2002). "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)". J. Biol. Chem. 277 (9): 7165–9. doi:10.1074/jbc.C100714200. PMID 11773063.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kalant D, Cain SA, Maslowska M, et al. (2003). "The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein". J. Biol. Chem. 278 (13): 11123–9. doi:10.1074/jbc.M206169200. PMID 12540846.
• Otto M, Hawlisch H, Monk PN, et al. (2004). "C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism". J. Biol. Chem. 279 (1): 142–51. doi:10.1074/jbc.M310078200. PMID 14570896.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Huber-Lang M, Sarma JV, Rittirsch D, et al. (2005). "Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans". J. Immunol. 174 (2): 1104–10. doi:10.4049/jimmunol.174.2.1104. PMID 15634936.
• Kalant D, MacLaren R, Cui W, et al. (2005). "C5L2 is a functional receptor for acylation-stimulating protein". J. Biol. Chem. 280 (25): 23936–44. doi:10.1074/jbc.M406921200. PMID 15833747.
• Johswich K, Martin M, Thalmann J, et al. (2007). "Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines". J. Biol. Chem. 281 (51): 39088–95. doi:10.1074/jbc.M609734200. PMID 17068344.
• Scola AM, Higginbottom A, Partridge LJ, et al. (2007). "THE ROLE OF THE N-TERMINAL DOMAIN OF THE COMPLEMENT FRAGMENT RECEPTOR, C5L2, IN LIGAND BINDING". J. Biol. Chem. 282 (6): 3664–71. doi:10.1074/jbc.M609178200. PMC 2873560. PMID 17158873.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

• "Complement Peptide Receptors: C5a2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.