Brain-specific angiogenesis inhibitor 2

ADGRB2
Identifiers
Aliases	ADGRB2, BAI2, adhesion G protein-coupled receptor B2
External IDs	OMIM: 602683; MGI: 2451244; HomoloGene: 1288; GeneCards: ADGRB2; OMA:ADGRB2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	31,764,893 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	129,916,426 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; anterior cingulate cortex; ; ganglionic eminence; ; dorsolateral prefrontal cortex; ; nucleus accumbens; ; caudate nucleus; ; Brodmann area 9; ; Brodmann area 10; ; amygdala;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; hippocampus proper; ; prefrontal cortex; ; piriform cortex; ; olfactory tubercle; ; primary motor cortex; ; cingulate gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity; signal transducer activity; G protein-coupled receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; centrosome; integral component of plasma membrane;
Biological process	negative regulation of angiogenesis; cell surface receptor signaling pathway; peripheral nervous system development; signal transduction; positive regulation of synapse assembly; G protein-coupled receptor signaling pathway; calcineurin-NFAT signaling cascade; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	576
	230775
	ENSG00000121753
	ENSMUSG00000028782
	O60241
	Q8CGM1
	NM_001294335; NM_001294336; NM_001364857
NM_001199696; NM_001290714; NM_001290715; NM_173071; NM_001377056;
	NM_001377057; NM_001377058
	NP_001281264; NP_001281265; NP_001351786
NP_001186625; NP_001277643; NP_001277644; NP_775094; NP_001363985;
	NP_001363986; NP_001363987
	Wikidata
View/Edit Human	View/Edit Mouse

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene.^[5]^[6] It is a member of the adhesion-GPCR family of receptors.^[7]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121753 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028782 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.
^ ^a ^b "Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2".
^ Stacey, edited by Simon Yona, Martin (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 9781441979124. {{cite book}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link)

Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Kee HJ, Koh JT, Kim MY, et al. (2002). "Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis". J. Cereb. Blood Flow Metab. 22 (9): 1054–67. doi:10.1097/00004647-200209000-00003. PMID 12218411.
Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell. Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121753 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028782 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9533023-5] Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.

[entrez-6] "Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2".

[7] Stacey, edited by Simon Yona, Martin (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 9781441979124. {{cite book}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link)

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References

Further reading