Endothelin receptor type A

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Endothelin receptor type A
Identifiers
Aliases EDNRA, ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR, MFDA, endothelin receptor type A
External IDs MGI: 105923 HomoloGene: 1478 GeneCards: 1909
Genetically Related Diseases
Disease Name References
cerebral aneurysm
RNA expression pattern
PBB GE EDNRA 204463 s at tn.png

PBB GE EDNRA 204464 s at tn.png

PBB GE EDNRA 216235 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166055
NM_001256283
NM_001957

NM_010332

RefSeq (protein)

NP_001159527.1
NP_001243212.1
NP_001948.1

NP_034462.1

Location (UCSC) Chr 4: 147.48 – 147.54 Mb Chr 8: 77.66 – 77.72 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor.[1]


Interactions[edit]

Endothelin receptor type A has been shown to interact with HDAC7A[2] and HTATIP.[2]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: EDNRA endothelin receptor type A". 
  2. ^ a b Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". The Journal of Biological Chemistry 276 (20): 16597–600. doi:10.1074/jbc.C000909200. PMID 11262386. 

External links[edit]

  • "Endothelin Receptors: ETA". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

  • Arai H, Nakao K, Hosoda K, Ogawa Y, Nakagawa O, Komatsu Y, Imura H (1993). "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]". Japanese Circulation Journal. 56 Suppl 5: 1303–7. doi:10.1253/jcj.56.supplementv_1303. PMID 1291713. 
  • Hosoda K, Nakao K, Tamura N, Arai H, Ogawa Y, Suga S, Nakanishi S, Imura H (September 1992). "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor". The Journal of Biological Chemistry 267 (26): 18797–804. PMID 1326535. 
  • Hayzer DJ, Rose PM, Lynch JS, Webb ML, Kienzle BK, Liu EC, Bogosian EA, Brinson E, Runge MS (October 1992). "Cloning and expression of a human endothelin receptor: subtype A". The American Journal of the Medical Sciences 304 (4): 231–8. doi:10.1097/00000441-199210000-00002. PMID 1415318. 
  • Hosoda K, Nakao K, Suga S, Ogawa Y, Mukoyama M, Shirakami G, Saito Y, Nakanishi S, Imura H (August 1991). "Cloning and expression of human endothelin-1 receptor cDNA". FEBS Letters 287 (1-2): 23–6. doi:10.1016/0014-5793(91)80007-P. PMID 1652463. 
  • Cyr C, Huebner K, Druck T, Kris R (November 1991). "Cloning and chromosomal localization of a human endothelin ETA receptor". Biochemical and Biophysical Research Communications 181 (1): 184–90. doi:10.1016/S0006-291X(05)81399-3. PMID 1659806. 
  • Adachi M, Yang YY, Furuichi Y, Miyamoto C (November 1991). "Cloning and characterization of cDNA encoding human A-type endothelin receptor". Biochemical and Biophysical Research Communications 180 (3): 1265–72. doi:10.1016/S0006-291X(05)81332-4. PMID 1719979. 
  • Lin HY, Kaji EH, Winkel GK, Ives HE, Lodish HF (April 1991). "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor". Proceedings of the National Academy of Sciences of the United States of America 88 (8): 3185–9. doi:10.1073/pnas.88.8.3185. PMC 51410. PMID 1849646. 
  • Takigawa M, Sakurai T, Kasuya Y, Abe Y, Masaki T, Goto K (February 1995). "Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors". European Journal of Biochemistry / FEBS 228 (1): 102–8. doi:10.1111/j.1432-1033.1995.tb20236.x. PMID 7882989. 
  • Kobayashi S, Tang R, Wang B, Opgenorth T, Langenstroer P, Shapiro E, Lepor H (February 1994). "Binding and functional properties of endothelin receptor subtypes in the human prostate". Molecular Pharmacology 45 (2): 306–11. PMID 8114678. 
  • Yang H, Tabuchi H, Furuichi Y, Miyamoto C (January 1993). "Molecular characterization of the 5'-flanking region of human genomic ETA gene". Biochemical and Biophysical Research Communications 190 (2): 332–9. doi:10.1006/bbrc.1993.1052. PMID 8427579. 
  • Elshourbagy NA, Korman DR, Wu HL, Sylvester DR, Lee JA, Nuthalaganti P, Bergsma DJ, Kumar CS, Nambi P (February 1993). "Molecular characterization and regulation of the human endothelin receptors". The Journal of Biological Chemistry 268 (6): 3873–9. PMID 8440682. 
  • Miyamoto Y, Yoshimasa T, Arai H, Takaya K, Ogawa Y, Itoh H, Nakao K (February 1996). "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts". The Biochemical Journal. 313 ( Pt 3) (3): 795–801. PMC 1216980. PMID 8611157. 
  • Horstmeyer A, Cramer H, Sauer T, Müller-Esterl W, Schroeder C (August 1996). "Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification". The Journal of Biological Chemistry 271 (34): 20811–9. doi:10.1074/jbc.271.34.20811. PMID 8702836. 
  • Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ (July 1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity". The Journal of Biological Chemistry 272 (28): 17734–43. doi:10.1074/jbc.272.28.17734. PMID 9211925. 
  • Bourgeois C, Robert B, Rebourcet R, Mondon F, Mignot TM, Duc-Goiran P, Ferré F (September 1997). "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3". The Journal of Clinical Endocrinology and Metabolism 82 (9): 3116–23. doi:10.1210/jc.82.9.3116. PMID 9284755. 
  • Mao XQ, Gao PS, Roberts MH, Enomoto T, Kawai M, Sasaki S, Shaldon SR, Coull P, Dake Y, Adra CN, Hagihara A, Shirakawa T, Hopkin JM (August 1999). "Variants of endothelin-1 and its receptors in atopic asthma". Biochemical and Biophysical Research Communications 262 (1): 259–62. doi:10.1006/bbrc.1999.1158. PMID 10448102. 
  • Maggi M, Barni T, Fantoni G, Mancina R, Pupilli C, Luconi M, Crescioli C, Serio M, Vannelli GB (April 2000). "Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons". The Journal of Clinical Endocrinology and Metabolism 85 (4): 1658–65. doi:10.1210/jc.85.4.1658. PMID 10770212. 
  • Shraga-Levine Z, Sokolovsky M (June 2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific". Cellular and Molecular Neurobiology 20 (3): 305–17. doi:10.1023/A:1007010125316. PMID 10789830. 
  • Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". The Journal of Biological Chemistry 276 (20): 16597–600. doi:10.1074/jbc.C000909200. PMID 11262386. 
  • Paasche JD, Attramadal T, Sandberg C, Johansen HK, Attramadal H (September 2001). "Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways". The Journal of Biological Chemistry 276 (36): 34041–50. doi:10.1074/jbc.M103243200. PMID 11382773. 
  • Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ (April 2016). "Endothelin". Pharmacological Reviews 68 (2): 357–418. doi:10.1124/pr.115.011833. PMID 26956245. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.