From Wikipedia, the free encyclopedia
  (Redirected from F4/80)
Jump to: navigation, search
Adhesion G protein-coupled receptor E1
Symbols ADGRE1 ; EMR1; TM7LN3
External IDs OMIM600493 MGI106912 HomoloGene1493 IUPHAR: GeneCards: ADGRE1 Gene
RNA expression pattern
PBB GE EMR1 207111 at tn.png
More reference expression data
Species Human Mouse
Entrez 2015 13733
Ensembl ENSG00000174837 ENSMUSG00000004730
UniProt Q14246 Q61549
RefSeq (mRNA) NM_001256252 NM_010130
RefSeq (protein) NP_001243181 NP_034260
Location (UCSC) Chr 19:
6.89 – 6.94 Mb
Chr 17:
57.36 – 57.48 Mb
PubMed search [1] [2]

EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene.[1][2][3][4][5] EMR1 is a member of the adhesion GPCR family.[6][7] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[8]

EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells.[9] The murine homolog of EMR1, F4/80, is a well-known and widely-used marker of murine macrophage populations.[10] The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.[11]


Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance.[12]

Clinical significance[edit]

Legrand et al. recently demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.[13]

See also[edit]


  1. ^ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA et al. (Mar 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460. 
  2. ^ McKnight AJ, Gordon S (Mar 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology 63 (3): 271–80. PMID 9500513. 
  3. ^ "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1". 
  4. ^ Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (Sep 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods 174 (1-2): 5–19. doi:10.1016/0022-1759(94)90005-1. PMID 8083537. 
  5. ^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.". Pharmacological reviews 67 (2): 338–67. PMID 25713288. 
  6. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  7. ^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage.". Science signaling 6 (276): re3. PMID 23695165. 
  8. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC et al. (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. 
  9. ^ Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M et al. (Oct 2007). "EMR1, the human homolog of F4/80, is an eosinophil-specific receptor". European Journal of Immunology 37 (10): 2797–802. doi:10.1002/eji.200737553. PMID 17823986. 
  10. ^ Austyn JM, Gordon S (Oct 1981). "F4/80, a monoclonal antibody directed specifically against the mouse macrophage". European Journal of Immunology 11 (10): 805–15. doi:10.1002/eji.1830111013. PMID 7308288. 
  11. ^ Gordon S, Hamann J, Lin HH, Stacey M (Sep 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology 41 (9): 2472–6. doi:10.1002/eji.201141715. PMID 21952799. 
  12. ^ Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J et al. (May 2005). "The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance". The Journal of Experimental Medicine 201 (10): 1615–25. doi:10.1084/jem.20042307. PMID 15883173. 
  13. ^ Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M et al. (May 2014). "The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders". The Journal of Allergy and Clinical Immunology 133 (5): 1439–47, 1447.e1–8. doi:10.1016/j.jaci.2013.11.041. PMID 24530099. 

External links[edit]