Gastric inhibitory polypeptide receptor

GIPR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HJ0, 2QKH
Identifiers
Aliases	GIPR, PGQTL2, gastric inhibitory polypeptide receptor
External IDs	OMIM: 137241; MGI: 1352753; HomoloGene: 20081; GeneCards: GIPR; OMA:GIPR - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,683,722 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	18,900,052 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; apex of heart; ; right auricle; ; olfactory zone of nasal mucosa; ; body of pancreas; ; granulocyte; ; body of stomach; ; islet of Langerhans; ; minor salivary glands; ; bronchial epithelial cell;
	Top expressed in
	islet of Langerhans; ; embryo; ; morula; ; spermatid; ; blastocyst; ; ventricular zone; ; ganglionic eminence; ; left lung lobe; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; gastric inhibitory peptide receptor activity; transmembrane signaling receptor activity; protein binding; peptide hormone binding; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	response to fatty acid; response to nutrient; regulation of insulin secretion; positive regulation of cytosolic calcium ion concentration; response to glucose; generation of precursor metabolites and energy; activation of adenylate cyclase activity; response to calcium ion; cell surface receptor signaling pathway; gastric inhibitory peptide signaling pathway; response to axon injury; desensitization of G protein-coupled receptor signaling pathway; endocrine pancreas development; signal transduction; positive regulation of insulin secretion; G protein-coupled receptor signaling pathway; positive regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	2696
	381853
	ENSG00000010310
	ENSMUSG00000030406
	P48546
	Q0P543
	NM_000164; NM_001308418
	NM_001080815
	NP_000155; NP_001295347
	NP_001074284
	Wikidata
View/Edit Human	View/Edit Mouse

The gastric inhibitory polypeptide receptor (GIP-R) also known as the glucose-dependent insulinotropic polypeptide receptor is a protein that in humans is encoded by the GIPR gene.^[5]^[6] The GIP-R is seven-transmembrane proteins found on beta-cells in the pancreas.^[7]^[8]

Function

Gastric inhibitory polypeptide (GIP), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000010310 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030406 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: gastric inhibitory polypeptide receptor".
^ Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609. doi:10.1006/geno.1995.1203. PMID 7490109.
^ "Gastrointestinal Hormones and Peptides". Retrieved 2007-08-24.
^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188. doi:10.1080/10606820213687. PMID 12529935.

External links

"Glucagon Receptor Family: GIP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
gastric+inhibitory+polypeptide+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Template:PBB Controls

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000010310 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030406 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: gastric inhibitory polypeptide receptor".

[pmid7490109-6] Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609. doi:10.1006/geno.1995.1203. PMID 7490109.

[Helmenstine-7] "Gastrointestinal Hormones and Peptides". Retrieved 2007-08-24.

[pmid12529935-8] Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188. doi:10.1080/10606820213687. PMID 12529935.

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Function

References

Further reading

External links