KLRD1

KLRD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B6E, 3BDW, 3CDG, 3CII
Identifiers
Aliases	KLRD1, CD94, killer cell lectin like receptor D1
External IDs	OMIM: 602894; MGI: 1196275; HomoloGene: 1705; GeneCards: KLRD1; OMA:KLRD1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,329,608 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	129,575,738 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; bone marrow; ; lymph node; ; bone marrow cells; ; upper lobe of left lung; ; testicle; ; mononuclear cell; ; gonad;
	Top expressed in
	blood; ; spleen; ; mesenteric lymph nodes; ; subcutaneous adipose tissue; ; thymus; ; jejunum; ; duodenum; ; granulocyte; ; bone marrow; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein antigen binding; MHC class Ib protein binding, via antigen binding groove; protein binding; transmembrane signaling receptor activity; MHC class I protein complex binding; carbohydrate binding;
Cellular component	integral component of membrane; receptor complex; plasma membrane; membrane; external side of plasma membrane;
Biological process	cell surface receptor signaling pathway; innate immune response; natural killer cell mediated immunity; regulation of immune response;
	Sources:Amigo / QuickGO
Orthologs
	3824
	16643
	ENSG00000134539
	ENSMUSG00000030165
	Q13241
	O54707
NM_001114396; NM_002262; NM_007334; NM_001351060; NM_001351062;
	NM_001351063
	NM_010654
NP_001107868; NP_002253; NP_031360; NP_001337989; NP_001337991;
	NP_001337992
	NP_034784
	Wikidata
View/Edit Human	View/Edit Mouse

CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene.^[5]

The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

Function

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.^[5]

Interactions

KLRD1 has been shown to interact with KLRC2.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134539 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030165 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: KLRD1 killer cell lectin-like receptor subfamily D, member 1".
^ Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". Journal of Immunology. 157 (11): 4741–5. doi:10.4049/jimmunol.157.11.4741. PMID 8943374.
^ Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology. 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637. S2CID 28500838.

Chang C, Rodríguez A, Carretero M, López-Botet M, Phillips JH, Lanier LL (Sep 1995). "Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily". European Journal of Immunology. 25 (9): 2433–7. doi:10.1002/eji.1830250904. PMID 7589107. S2CID 26887028.
Moretta A, Vitale M, Sivori S, Bottino C, Morelli L, Augugliaro R, Barbaresi M, Pende D, Ciccone E, Lopez-Botet M, Moretta L (Aug 1994). "Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles". The Journal of Experimental Medicine. 180 (2): 545–55. doi:10.1084/jem.180.2.545. PMC 2191622. PMID 8046333.
Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL (Aug 1996). "CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes". Immunity. 5 (2): 163–72. doi:10.1016/S1074-7613(00)80492-6. PMID 8769479.
Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". Journal of Immunology. 157 (11): 4741–5. doi:10.4049/jimmunol.157.11.4741. PMID 8943374.
Brooks AG, Posch PE, Scorzelli CJ, Borrego F, Coligan JE (Feb 1997). "NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor". The Journal of Experimental Medicine. 185 (4): 795–800. doi:10.1084/jem.185.4.795. PMC 2196137. PMID 9034158.
Mandelboim O, Pazmany L, Davis DM, Valés-Gómez M, Reyburn HT, Rybalov B, Strominger JL (Dec 1997). "Multiple receptors for HLA-G on human natural killer cells". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14666–70. Bibcode:1997PNAS...9414666M. doi:10.1073/pnas.94.26.14666. PMC 25087. PMID 9405670.
Rodríguez A, Carretero M, Glienke J, Bellón T, Ramírez A, Lehrach H, Francis F, López-Botet M (Mar 1998). "Structure of the human CD94 C-type lectin gene". Immunogenetics. 47 (4): 305–9. doi:10.1007/s002510050362. PMID 9472066. S2CID 9012702.
Le Dréan E, Vély F, Olcese L, Cambiaggi A, Guia S, Krystal G, Gervois N, Moretta A, Jotereau F, Vivier E (Jan 1998). "Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases". European Journal of Immunology. 28 (1): 264–76. doi:10.1002/(SICI)1521-4141(199801)28:01<264::AID-IMMU264>3.0.CO;2-O. PMID 9485206.
Braud VM, Allan DS, O'Callaghan CA, Söderström K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ (Feb 1998). "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C". Nature. 391 (6669): 795–9. Bibcode:1998Natur.391..795B. doi:10.1038/35869. PMID 9486650. S2CID 4379457.
Plougastel B, Trowsdale J (Apr 1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes". Genomics. 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306.
Furukawa H, Yabe T, Watanabe K, Miyamoto R, Akaza T, Tadokoro K, Tohma S, Inoue T, Yamamoto K, Juji T (Jun 1998). "An alternatively spliced form of the human CD94 gene". Immunogenetics. 48 (1): 87–8. doi:10.1007/s002510050407. PMID 9601951. S2CID 29944586.
Lanier LL, Corliss B, Wu J, Phillips JH (Jun 1998). "Association of DAP12 with activating CD94/NKG2C NK cell receptors". Immunity. 8 (6): 693–701. doi:10.1016/S1074-7613(00)80574-9. PMID 9655483.
Vance RE, Kraft JR, Altman JD, Jensen PE, Raulet DH (Nov 1998). "Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b)". The Journal of Experimental Medicine. 188 (10): 1841–8. doi:10.1084/jem.188.10.1841. PMC 2212405. PMID 9815261.
Brooks AG, Borrego F, Posch PE, Patamawenu A, Scorzelli CJ, Ulbrecht M, Weiss EH, Coligan JE (Jan 1999). "Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells". Journal of Immunology. 162 (1): 305–13. doi:10.4049/jimmunol.162.1.305. PMID 9886400.
Boyington JC, Riaz AN, Patamawenu A, Coligan JE, Brooks AG, Sun PD (Jan 1999). "Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors". Immunity. 10 (1): 75–82. doi:10.1016/S1074-7613(00)80008-4. PMID 10023772.
Bellón T, Heredia AB, Llano M, Minguela A, Rodriguez A, López-Botet M, Aparicio P (Apr 1999). "Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer". Journal of Immunology. 162 (7): 3996–4002. doi:10.4049/jimmunol.162.7.3996. PMID 10201920.
Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology. 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637. S2CID 28500838.
Romero P, Ortega C, Palma A, Molina IJ, Peña J, Santamaría M (Aug 2001). "Expression of CD94 and NKG2 molecules on human CD4(+) T cells in response to CD3-mediated stimulation". Journal of Leukocyte Biology. 70 (2): 219–24. doi:10.1189/jlb.70.2.219. PMID 11493613. S2CID 38552860.
Shum BP, Flodin LR, Muir DG, Rajalingam R, Khakoo SI, Cleland S, Guethlein LA, Uhrberg M, Parham P (Jan 2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes". Journal of Immunology. 168 (1): 240–52. doi:10.4049/jimmunol.168.1.240. PMID 11751968.
Terrazzano G, Zanzi D, Palomba C, Carbone E, Grimaldi S, Pisanti S, Fontana S, Zappacosta S, Ruggiero G (Aug 2002). "Differential involvement of CD40, CD80, and major histocompatibility complex class I molecules in cytotoxicity induction and interferon-gamma production by human natural killer effectors". Journal of Leukocyte Biology. 72 (2): 305–11. doi:10.1189/jlb.72.2.305. PMID 12149421. S2CID 26932214.

External links

CD94+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134539 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030165 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KLRD1 killer cell lectin-like receptor subfamily D, member 1".

[pmid8943374-6] Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". Journal of Immunology. 157 (11): 4741–5. doi:10.4049/jimmunol.157.11.4741. PMID 8943374.

[pmid10320637-7] Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology. 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637. S2CID 28500838.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

KLRD1

Function

Interactions

See also

References

Further reading

External links