Hypocretin (orexin) receptor 1

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HCRTR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHCRTR1, OX1R, Hypocretin (orexin) receptor 1, hypocretin receptor 1
External IDsOMIM: 602392 MGI: 2385650 HomoloGene: 37492 GeneCards: HCRTR1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HCRTR1
Genomic location for HCRTR1
Band1p35.2Start31,617,686 bp[1]
End31,632,518 bp[1]
RNA expression pattern
PBB GE HCRTR1 207619 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001525

NM_001163027
NM_198959
NM_001305392
NM_001357258

RefSeq (protein)

NP_001516

NP_001156499
NP_001292321
NP_945197
NP_001344187

Location (UCSC)Chr 1: 31.62 – 31.63 MbChr 4: 130.13 – 130.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.[5]

Function[edit]

The orexin 1 receptor (OX1), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.[5]

Ligands[edit]

Agonists[edit]

Antagonists[edit]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121764 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028778 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1".
  6. ^ "Eisai Demonstrates Efficacy of Investigational Dual Orexin Receptor Antagonist E2006 in Sleep Initiation and Maintenance Data from Phase II Clinical Trial for Insomnia".

External links[edit]

  • "Orexin Receptors: OX1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.