Prokineticin receptor 2

PROKR2
Identifiers
Aliases	PROKR2, GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3, prokineticin receptor 2
External IDs	OMIM: 607123; MGI: 2181363; HomoloGene: 16368; GeneCards: PROKR2; OMA:PROKR2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20p12.3 Start 5,299,218 bp End 5,316,954 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 F2 Start 132,179,653 bp End 132,227,367 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone prefrontal cortex Brodmann area 9 anterior cingulate cortex lymph node right frontal lobe bone marrow hippocampus proper superior frontal gyrus Top expressed in Rostral migratory stream lumbar spinal ganglion suprachiasmatic nucleus tail of embryo medial ganglionic eminence olfactory bulb Gonadal ridge thymus Sertoli cell anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity neuropeptide Y receptor activity pancreatic polypeptide receptor activity G protein-coupled receptor activity Cellular component membrane integral component of membrane plasma membrane integral component of plasma membrane Biological process circadian rhythm signal transduction neuropeptide signaling pathway chemical synaptic transmission feeding behavior blood circulation G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 128674 246313 Ensembl ENSG00000101292 ENSMUSG00000050558 UniProt Q8NFJ6 Q8K458 RefSeq (mRNA) NM_144773 NM_144944 RefSeq (protein) NP_658986 NP_659193 Location (UCSC) Chr 20: 5.3 – 5.32 Mb Chr 2: 132.18 – 132.23 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Prokineticin receptor 2 (PKR₂), is a G protein-coupled receptor encoded by the PROKR2 gene in humans.

Function

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.

Mutations in the PROKR2 (also known as KAL3) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.

See also

• Prokineticin receptor
• Kallmann syndrome

Further reading

• Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY (May 2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor". The Journal of Biological Chemistry. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Soga T, Matsumoto Si, Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K (December 2002). "Molecular cloning and characterization of prokineticin receptors". Biochimica et Biophysica Acta. 1579 (2–3): 173–9. doi:10.1016/S0167-4781(02)00546-8. PMID 12427552.
• Battersby S, Critchley HO, Morgan K, Millar RP, Jabbour HN (May 2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle". The Journal of Clinical Endocrinology and Metabolism. 89 (5): 2463–9. doi:10.1210/jc.2003-032012. PMID 15126578.
• Pasquali D, Rossi V, Staibano S, De Rosa G, Chieffi P, Prezioso D, Mirone V, Mascolo M, Tramontano D, Bellastella A, Sinisi AA (September 2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy". Endocrinology. 147 (9): 4245–51. doi:10.1210/en.2006-0614. PMID 16763065.
• Dodé C, Teixeira L, Levilliers J, Fouveaut C, Bouchard P, Kottler ML, Lespinasse J, Lienhardt-Roussie A, Mathieu M, Moerman A, Morgan G, Murat A, Toublanc JE, Wolczynski S, Delpech M, Petit C, Young J, Hardelin JP (October 2006). "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2". PLoS Genetics. 2 (10): e175. doi:10.1371/journal.pgen.0020175. PMC 1617130. PMID 17054399.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

• GeneReviews/NCBI/NIH/UW entry on Kallmann syndrome
• "Prokineticin Receptors: PKR₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.