Langerin

CD207
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C22, 3KQG, 3P5D, 3P5E, 3P5F, 3P5G, 3P5H, 3P5I, 3P7F, 3P7G, 3P7H, 4AK8, 4N32, 4N33, 4N34, 4N35, 4N36, 4N37, 4N38
Identifiers
Aliases	CD207, CLEC4K, CD207 molecule
External IDs	OMIM: 604862; MGI: 2180021; HomoloGene: 9252; GeneCards: CD207; OMA:CD207 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p13.3 Start 70,830,211 bp End 70,835,816 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 C3 Start 83,648,197 bp End 83,654,839 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip skin of abdomen skin of arm vulva nipple epithelium of esophagus oral cavity gums gingival epithelium Top expressed in skin of external ear thymus lip skin of abdomen liver spleen left lobe of liver right lung lobe skin of back neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function mannose binding carbohydrate binding protein binding Cellular component integral component of membrane clathrin-coated endocytic vesicle membrane plasma membrane endocytic vesicle early endosome membrane membrane Biological process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent defense response to virus receptor-mediated endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50489 246278 Ensembl ENSG00000116031 ENSMUSG00000034783 UniProt Q9UJ71 Q8VBX4 RefSeq (mRNA) NM_015717 NM_144943 RefSeq (protein) NP_056532 NP_659192 Location (UCSC) Chr 2: 70.83 – 70.84 Mb Chr 6: 83.65 – 83.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene. Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.

Function

The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it is known by the name C-type lectin domain family 4 member K (CD antigen CD207). It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.

Clinical significance

Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.

See also

• Paul Langerhans
• Langerhans cell

Further reading

• Valladeau J, Dezutter-Dambuyant C, Saeland S (2003). "Langerin/CD207 Sheds Light on Formation of Birbeck Granules and Their Possible Function in Langerhans Cells". Immunologic Research. 28 (2): 93–107. doi:10.1385/IR:28:2:93. PMID 14610287.
• Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". The FASEB Journal. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• The Sanger Centre, The Washington University Genome Sequencing Center (1998). "Toward a Complete Human Genome Sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Valladeau J; Ravel O; Dezutter-Dambuyant C; Moore K; Kleijmeer M; Liu Y; Duvert-Frances Vé; Vincent C; Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity. 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
• Turville SG, Cameron PU, Handley A, Lin G, Pöhlmann S, Doms RW, Cunningham AL (2002). "Diversity of receptors binding HIV on dendritic cell subsets". Nature Immunology. 3 (10): 975–83. doi:10.1038/ni841. PMID 12352970.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A (2004). "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells". Journal of Clinical Investigation. 113 (5): 701–8. doi:10.1172/JCI19655. PMC 351318. PMID 14991068.
• Vashishta A, Fusek M, Větvička V (2005). "Possible role of procathepsin D in human cancer". Folia Microbiologica. 50 (1): 71–6. doi:10.1007/BF02931296. PMID 15954536.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Research. 14 (10b): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Verdijk P, Dijkman R, Plasmeijer EI, Mulder AA, Zoutman WH, Mieke Mommaas A, Tensen CP (2005). "A Lack of Birbeck Granules in Langerhans Cells is Associated with a Naturally Occurring Point Mutation in the Human Langerin Gene". Journal of Investigative Dermatology. 124 (4): 714–7. doi:10.1111/j.0022-202X.2005.23645.x. PMID 15816828.
• Bousarghin L (2005). "Human papillomavirus 16 virus-like particles use heparan sulfates to bind dendritic cells and colocalize with langerin in Langerhans cells". Journal of General Virology. 86 (5): 1297–1305. doi:10.1099/vir.0.80559-0. PMID 15831940.
• He B, Qiao X, Klasse PJ, Chiu A, Chadburn A, Knowles DM, Moore JP, Cerutti A (2006). "HIV-1 Envelope Triggers Polyclonal Ig Class Switch Recombination through a CD40-Independent Mechanism Involving BAFF and C-Type Lectin Receptors". Journal of Immunology. 176 (7): 3931–41. doi:10.4049/jimmunol.176.7.3931. PMID 16547227.
• Ward EM, Stambach NS, Drickamer K, Taylor ME (2006). "Polymorphisms in Human Langerin Affect Stability and Sugar Binding Activity". Journal of Biological Chemistry. 281 (22): 15450–6. doi:10.1074/jbc.M511502200. PMID 16567809.
• de Witte L; Nabatov A; Pion M; Fluitsma D; De Jong MAWP; De Gruijl T; Piguet V; Van Kooyk Y; Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine. 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373.
• Kaplan DH, Li MO, Jenison MC, Shlomchik WD, Flavell RA, Shlomchik MJ (2007). "Autocrine/paracrine TGF 1 is required for the development of epidermal Langerhans cells". Journal of Experimental Medicine. 204 (11): 2545–52. doi:10.1084/jem.20071401. PMC 2118472. PMID 17938236.

External links

• CD207 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q9UJ71 (C-type lectin domain family 4 member K) at the PDBe-KB.