Relaxin/insulin-like family peptide receptor 1

RXFP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JM4, 2M7P
Identifiers
Aliases	RXFP1, LGR7, RXFPR1, Relaxin/insulin-like family peptide receptor 1, relaxin/insulin like family peptide receptor 1, relaxin family peptide receptor 1
External IDs	OMIM: 606654; MGI: 2682211; HomoloGene: 11007; GeneCards: RXFP1; OMA:RXFP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q32.1 Start 158,315,311 bp End 158,653,372 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 E3 Start 79,548,918 bp End 79,645,187 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell endometrium Brodmann area 46 prefrontal cortex Brodmann area 9 superior frontal gyrus Brodmann area 23 cingulate gyrus postcentral gyrus stromal cell of endometrium Top expressed in uterus superior frontal gyrus cervix atrioventricular valve hippocampus proper cerebellar cortex olfactory bulb thymus ventricle carotid body More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity protein binding signal transducer activity metal ion binding G protein-coupled peptide receptor activity Cellular component integral component of membrane membrane plasma membrane intracellular anatomical structure integral component of plasma membrane Biological process signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway activation of adenylate cyclase activity hormone-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59350 381489 Ensembl ENSG00000171509 ENSMUSG00000034009 UniProt Q9HBX9 Q6R6I7 RefSeq (mRNA) NM_001253727 NM_001253728 NM_001253729 NM_001253730 NM_001253732 NM_001253733 NM_021634 NM_001363776 NM_212452 RefSeq (protein) NP_001240656 NP_001240657 NP_001240658 NP_001240659 NP_001240661 NP_001240662 NP_067647 NP_001350705 NP_997617 Location (UCSC) Chr 4: 158.32 – 158.65 Mb Chr 3: 79.55 – 79.65 Mb PubMed search
Wikidata
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Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human G protein coupled receptor that is one of the relaxin receptors.

See also

• Relaxin family peptide hormones
• Insulin/IGF/Relaxin family
• Relaxin
  • Relaxin-3

Further reading

• Bathgate RA, Ivell R, Sanborn BM, et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688. S2CID 1185573.
• Bathgate RA, Ivell R, Sanborn BM, et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. S2CID 7466039.
• Hsu SY, Kudo M, Chen T, et al. (2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol. Endocrinol. 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549.
• Bartsch O, Bartlick B, Ivell R (2001). "Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity". Mol. Hum. Reprod. 7 (9): 799–809. doi:10.1093/molehr/7.9.799. PMID 11517286.
• Hsu SY, Nakabayashi K, Nishi S, et al. (2002). "Activation of orphan receptors by the hormone relaxin". Science. 295 (5555): 671–4. doi:10.1126/science.1065654. PMID 11809971. S2CID 32693420.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sudo S, Kumagai J, Nishi S, et al. (2003). "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2". J. Biol. Chem. 278 (10): 7855–62. doi:10.1074/jbc.M212457200. PMID 12506116.
• Ivell R, Balvers M, Pohnke Y, et al. (2004). "Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates". Reprod. Biol. Endocrinol. 1: 114. doi:10.1186/1477-7827-1-114. PMC 293425. PMID 14633277.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Luna JJ, Riesewijk A, Horcajadas JA, et al. (2004). "Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle". Mol. Hum. Reprod. 10 (2): 85–90. doi:10.1093/molehr/gah019. PMID 14742692.
• Bond CP, Parry LJ, Samuel CS, et al. (2004). "Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle". J. Clin. Endocrinol. Metab. 89 (7): 3477–85. doi:10.1210/jc.2003-030798. PMID 15240635.
• Liu C, Chen J, Kuei C, et al. (2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Mol. Pharmacol. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925. S2CID 25164369.
• Scott DJ, Layfield S, Riesewijk A, et al. (2005). "Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7". Clin. Exp. Pharmacol. Physiol. 31 (11): 828–32. doi:10.1111/j.1440-1681.2004.04075.x. PMID 15566402. S2CID 22463239.
• Büllesbach EE, Schwabe C (2005). "The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7". J. Biol. Chem. 280 (14): 14051–6. doi:10.1074/jbc.M500030200. PMID 15695505.
• Tang M, Mazella J, Zhu HH, Tseng L (2005). "Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells". Mol. Hum. Reprod. 11 (4): 237–43. doi:10.1093/molehr/gah149. PMID 15722441.
• Hopkins EJ, Bathgate RA, Gooley PR (2005). "The human LGR7 low-density lipoprotein class A module requires calcium for structure". Ann. N. Y. Acad. Sci. 1041: 27–34. doi:10.1196/annals.1282.006. PMID 15956684. S2CID 12876694.
• Bond CP, Parry LJ, Samuel CS, et al. (2005). "Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle". Ann. N. Y. Acad. Sci. 1041: 136–43. doi:10.1196/annals.1282.020. PMID 15956698. S2CID 38242216.
• Halls ML, Bathgate RA, Summers RJ (2005). "Signal switching after stimulation of LGR7 receptors by human relaxin 2". Ann. N. Y. Acad. Sci. 1041: 288–91. doi:10.1196/annals.1282.042. PMID 15956719. S2CID 42606513.
• Muda M, He C, Martini PG, et al. (2005). "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity". Mol. Hum. Reprod. 11 (8): 591–600. doi:10.1093/molehr/gah205. PMID 16051677.

External links

• "Relaxin Family Peptide Receptors: RXFP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.