Neuropeptide FF receptor 2

NPFFR2
Identifiers
Aliases	NPFFR2, GPR74, HLWAR77, NPFF2, NPGPR, neuropeptide FF receptor 2
External IDs	OMIM: 607449; MGI: 1860130; HomoloGene: 56982; GeneCards: NPFFR2; OMA:NPFFR2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q13.3 Start 72,031,902 bp End 72,148,305 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E1 Start 89,675,288 bp End 89,731,599 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta islet of Langerhans prefrontal cortex parietal pleura gastric mucosa seminal vesicula Brodmann area 9 appendix Achilles tendon rectum Top expressed in secondary oocyte spinal ganglia olfactory bulb testicle trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function opioid receptor binding peptide binding G protein-coupled receptor activity signal transducer activity neuropeptide receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane actin cytoskeleton Biological process G protein-coupled receptor signaling pathway detection of abiotic stimulus cellular response to hormone stimulus regulation of MAPK cascade regulation of adenylate cyclase activity regulation of cAMP-dependent protein kinase activity signal transduction response to peptide neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10886 104443 Ensembl ENSG00000056291 ENSMUSG00000035528 UniProt Q9Y5X5 Q924H0 RefSeq (mRNA) NM_001144756 NM_004885 NM_053036 NM_133192 RefSeq (protein) NP_001138228 NP_004876 NP_444264 NP_573455 Location (UCSC) Chr 4: 72.03 – 72.15 Mb Chr 5: 89.68 – 89.73 Mb PubMed search
Wikidata
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Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.

See also

• Neuropeptide FF receptor

Further reading

• Cikos S, Gregor P, Koppel J (1999). "Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta". Biochem. Biophys. Res. Commun. 256 (2): 352–6. doi:10.1006/bbrc.1999.0332. PMID 10079187.
• Parker RM, Copeland NG, Eyre HJ, et al. (2000). "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family". Brain Res. Mol. Brain Res. 77 (2): 199–208. doi:10.1016/S0169-328X(00)00052-8. PMID 10837915.
• Elshourbagy NA, Ames RS, Fitzgerald LR, et al. (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc.M004515200. PMID 10851242.
• Bonini JA, Jones KA, Adham N, et al. (2001). "Identification and characterization of two G protein-coupled receptors for neuropeptide FF". J. Biol. Chem. 275 (50): 39324–31. doi:10.1074/jbc.M004385200. PMID 11024015.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Laemmle B, Schindler M, Beilmann M, et al. (2003). "Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus". Regul. Pept. 111 (1–3): 21–9. doi:10.1016/S0167-0115(02)00220-3. PMID 12609745. S2CID 24049458.
• Engström M, Wurster S, Savola JM, Panula P (2004). "Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors". Peptides. 24 (12): 1947–54. doi:10.1016/j.peptides.2003.10.009. PMID 15127947. S2CID 3833336.
• Mollereau C, Mazarguil H, Zajac JM, Roumy M (2005). "Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells". Mol. Pharmacol. 67 (3): 965–75. doi:10.1124/mol.104.004614. PMID 15608144. S2CID 9919973.
• Ankö ML, Panula P (2006). "Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line". J. Neurochem. 96 (2): 573–84. doi:10.1111/j.1471-4159.2005.03581.x. PMID 16336216. S2CID 26460239.
• Ankö ML, Ostergård M, Lintunen M, Panula P (2007). "Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression". FEBS Lett. 580 (30): 6955–60. doi:10.1016/j.febslet.2006.11.063. PMID 17157836. S2CID 29801987.
• Dahlman I, Dicker A, Jiao H, et al. (2007). "A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis". Am. J. Hum. Genet. 80 (6): 1115–24. doi:10.1086/518445. PMC 1867099. PMID 17503329.

External links

• "Neuropeptide FF Receptors: NPFF2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.