From Wikipedia, the free encyclopedia
CD79 (C luster of D ifferentiation79 ) is a transmembrane protein that forms a complex with the B-cell receptor (BCR) and generates a signal following recognition of antigen by the BCR. CD79 is composed of two distinct chains called CD79A and CD79B (formerly known as Ig-alpha and Ig-beta); these form a heterodimer on the surface of a B cell stabilized by disulfide bonding .[ 1] immunoglobulin superfamily . Human CD79a is encoded by the mb-1 gene that is located on chromosome 19 , and CD79b is encoded by the B29 gene that located on chromosome 17 .[ 1] [ 2] immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails that they use to propagate a signal in a B cell, in a similar manner to CD3 -generated signal tranduction observed during T cell receptor activation on T cells .[ 3]
References
^ a b Chu P, Arber D (2001). "CD79: a review". Appl Immunohistochem Mol Morphol . 9 (2): 97–106. doi :10.1097/00022744-200106000-00001 . PMID 11396639 . ^ Van Noesel C, Brouns G, van Schijndel G, Bende R, Mason D, Borst J, van Lier R (1992). "Comparison of human B cell antigen receptor complexes: membrane- expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers" . J Exp Med . 175 (6): 1511–9. doi :10.1084/jem.175.6.1511 . PMC 2119249 PMID 1375264 . ^ Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol Lett . 44 (2–3): 97–103. doi :10.1016/0165-2478(94)00199-2 . PMID 7541024 .
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