Growth-hormone-releasing hormone receptor

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GHRHR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor, IGHD4
External IDsOMIM: 139191 MGI: 95710 HomoloGene: 640 GeneCards: GHRHR
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GHRHR
Genomic location for GHRHR
Band7p14.3Start30,938,669 bp[1]
End30,993,254 bp[1]
RNA expression pattern
PBB GE GHRHR 211544 s at fs.png

PBB GE GHRHR 207825 s at fs.png

PBB GE GHRHR 211545 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000823
NM_001009824

NM_001003685

RefSeq (protein)

NP_000814

NP_001003685

Location (UCSC)Chr 7: 30.94 – 30.99 MbChr 6: 55.38 – 55.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via adenylate cyclase.[5]

Function[edit]

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.[6]

Ligands[edit]

Agonists[edit]

Antagonists[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106128 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004654 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gaylinn BD (2002). "Growth hormone releasing hormone receptor". Receptors & Channels. 8 (3–4): 155–62. doi:10.1080/10606820213679. PMID 12529933.
  6. ^ "Entrez Gene: GHRHR growth hormone releasing hormone receptor".
  7. ^ Kovács M, Schally AV, Zarándi M, Groot K (1997). "Inhibition of GH release of rats by new potent antagonists of growth hormone-releasing hormone (GH-RH)". Peptides. 18 (3): 431–8. doi:10.1016/S0196-9781(96)00334-8. PMID 9145432. S2CID 24368945.
  8. ^ Banks WA, Morley JE, Farr SA, Price TO, Ercal N, Vidaurre I, Schally AV (Dec 2010). "Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice". Proceedings of the National Academy of Sciences of the United States of America. 107 (51): 22272–7. doi:10.1073/pnas.1016369107. PMC 3009756. PMID 21135231.

Further reading[edit]

External links[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.