LGR4

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LGR4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LGR4, BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4
External IDs MGI: 1891468 HomoloGene: 10226 GeneCards: LGR4
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for LGR4
Genomic location for LGR4
Band 11p14.1 Start 27,365,961 bp[1]
End 27,472,775 bp[1]
RNA expression pattern
PBB GE LGR4 218326 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018490
NM_001346432

NM_172671

RefSeq (protein)

NP_001333361
NP_060960

NP_766259

Location (UCSC) Chr 11: 27.37 – 27.47 Mb Chr 2: 109.92 – 110.01 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.[5][6] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).


References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205213 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050199 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923. 
  6. ^ "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4". 

Further reading[edit]