Latrophilin 3

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ADGRL3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ADGRL3, CIRL3, LEC3, CL3, LPHN3, adhesion G protein-coupled receptor L3
External IDs MGI: 2441950 HomoloGene: 22878 GeneCards: ADGRL3
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015236
NM_001322246
NM_001322402

NM_198702
NM_001347367
NM_001347368
NM_001347369
NM_001347371

RefSeq (protein)

NP_001309175
NP_001309331
NP_056051

NP_001334296
NP_001334297
NP_001334298
NP_001334300
NP_941991

Location (UCSC) Chr 4: 61.2 – 62.08 Mb Chr 5: 81.02 – 81.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.[3][4]

Function[edit]

This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.[4]

Clinical significance[edit]

A version of this gene has been linked to Attention Deficit/Hyperactivity Disorder (ADHD).[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2-3): 119–31. PMID 10994649. doi:10.3109/10799890009150640. 
  4. ^ a b "Entrez Gene: LPHN3 latrophilin 3". 
  5. ^ Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, et al. (Nov 2010). "A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication" (PDF). Molecular Psychiatry. 15 (11): 1053–66. PMID 20157310. doi:10.1038/mp.2010.6. 

Further reading[edit]

  • Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annual Review of Neuroscience. 24: 933–62. PMID 11520923. doi:10.1146/annurev.neuro.24.1.933. 
  • Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–42. PMID 15066411. doi:10.1016/j.toxicon.2004.02.008. 
  • Soares MB, Bonaldo MF, Jelene P, Su L, Lawton L, Efstratiadis A (Sep 1994). "Construction and characterization of a normalized cDNA library". Proceedings of the National Academy of Sciences of the United States of America. 91 (20): 9228–32. PMC 44785Freely accessible. PMID 7937745. doi:10.1073/pnas.91.20.9228. 
  • "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. Nov 1998. PMID 9847074. doi:10.1101/gr.8.11.1097. 
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. PMID 9872452. doi:10.1093/dnares/5.5.277. 
  • Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". The Journal of Biological Chemistry. 275 (42): 32387–90. PMID 10964907. doi:10.1074/jbc.C000490200. 
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. PMID 15203201. doi:10.1016/j.ygeno.2003.12.004. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.