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Benzydamine

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Benzydamine
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • AU: B2
Routes of
administration		Oral, topical
ATC code
Legal status
Legal status
  • OTC(UK)
Pharmacokinetic data
Protein binding<20%
Elimination half-life13 hours
ExcretionRenal
Identifiers
  • 3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.010.354 Edit this at Wikidata
Chemical and physical data
FormulaC19H23N3O
Molar mass309.405 g/mol g·mol−1
3D model (JSmol)
  • n2c(OCCCN(C)C)c1ccccc1n2Cc3ccccc3
  • InChI=1S/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3 checkY
  • Key:CNBGNNVCVSKAQZ-UHFFFAOYSA-N checkY
  (verify)

Benzydamine, available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat.[1]

Medical use

It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.

Contraindications

There are no contraindications to the use of Benzydamine except for known hypersensitivity.

Side effects

Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur.

Pharmacology

It selectively binds to inflamed tissues (Prostaglandin synthetase inhibitor) and is normally free of adverse systemic effects. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic.[2]

Recreational use

Benzydamine has been misused recreationally. In overdosages it acts a deliriant and CNS stimulant.[2] Such misuse, particularly among teenagers, has been reported in Poland,[2] Brazil[3][4] and Romania.

See also

References

  1. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 7600413 , please use {{cite journal}} with |pmid= 7600413 instead.
  2. ^ a b c Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17364645 , please use {{cite journal}} with |pmid= 17364645 instead.
  3. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19784487 , please use {{cite journal}} with |pmid= 19784487 instead.
  4. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20464184 , please use {{cite journal}} with |pmid= 20464184 instead.
  • "Benzydamine oral rinse". Medicinenet.
  • "Difflam spray (benzydamine)". Net Doctor, UK.
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