LGR6

LGR6
Identifiers
Aliases	LGR6, GPCR, VTS20631, leucine-rich repeat containing G protein-coupled receptor 6, leucine rich repeat containing G protein-coupled receptor 6
External IDs	OMIM: 606653; MGI: 2441805; HomoloGene: 49680; GeneCards: LGR6; OMA:LGR6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,319,781 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	135,033,014 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; ascending aorta; ; left coronary artery; ; gastric mucosa; ; popliteal artery; ; anterior pituitary; ; right uterine tube; ; gallbladder; ; lactiferous duct; ; tibia;
	Top expressed in
	ascending aorta; ; aortic valve; ; molar; ; secondary oocyte; ; right ventricle; ; median eminence; ; skin of back; ; epidermis; ; myocardium of ventricle; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity; protein-hormone receptor activity; heparin binding; Roundabout binding;
Cellular component	integral component of membrane; vesicle; plasma membrane; integral component of plasma membrane; trans-Golgi network membrane; membrane; extracellular space;
Biological process	positive regulation of canonical Wnt signaling pathway; positive regulation of Wnt signaling pathway; G protein-coupled receptor signaling pathway; Wnt signaling pathway; signal transduction; positive regulation of cell migration; tissue regeneration; bone regeneration; axon guidance; negative chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	59352
	329252
	ENSG00000133067
	ENSMUSG00000042793
	Q9HBX8
	Q3UVD5
	NM_001017403; NM_001017404; NM_021636
	NM_001033409
	NP_001017403; NP_001017404; NP_067649
	NP_001028581
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene.^[5]^[6] Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo.^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133067 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042793 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol Endocrinol. 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549.
^ "Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6".
^ Huang, Phillips Y.; Kandyba, Eve; Jabouille, Arnaud; Sjolund, Jonas; Kumar, Atul; Halliwill, Kyle; McCreery, Melissa; DelRosario, Reyno; Kang, Hio Chung (2017). "Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma". Nature Genetics. 49 (11): 1624–1632. doi:10.1038/ng.3957.

References

Further reading