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Benzydamine

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Benzydamine
Clinical data
Pregnancy
category
  • AU: B2
Routes of
administration		Oral, topical
ATC code
Legal status
Legal status
  • OTC(UK)
Pharmacokinetic data
Protein binding<20%
Elimination half-life13 hours
ExcretionRenal
Identifiers
  • 3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
ECHA InfoCard100.010.354 Edit this at Wikidata
Chemical and physical data
FormulaC19H23N3O
Molar mass309.405 g/mol g·mol−1
3D model (JSmol)
  • n2c(OCCCN(C)C)c1ccccc1n2Cc3ccccc3
  (verify)

Benzydamine, available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties providing both rapid and extended pain relief as well as a significant anti-inflammatory treatment for the painful inflammatory conditions of the mouth and throat.[1]

It selectively binds to inflamed tissues (Prostaglandin synthetase inhibitor) is virtually free of any adverse systemic effects.

It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.

Availability

It is available in a mouth wash named Tantum Verde and Tantum Rosa across Europe.

It is available in gel or oral rinse form with trade name Tantum (Elder Pharmaceutical) in India

In the UK it is available without prescription from pharmacies; it is produced in the UK by Meda Pharmaceuticals under the trade name Difflam, and is available as a spray, oral rinse and cream, and as lozenges.

In Sweden it is sold by Antula Healthcare, under he trade name Zyx, as lozenges.

In Australia it is available from 3M as Difflam-C Alcohol & Colour Free Solution, Difflam 3% Gel, Difflam Extra Strength Gel 5%, Difflam-C Solution, Difflam Solution (including Difflam Throat Spray), Difflam Cream and Difflam Lozenges.[2]

It is sold in eastern Europe without prescription as Tantum Rosa - a vaginal antiseptic and anti-inflammatory, containing 0.5 g of benzydamine hydrochloride to be reconstituted with clean water to a 0.1% (1 mg/mL) solution for vaginal enema/instillation.

In Brazil it is sold over-the-counter under the name "Benflogin", with each box containing 20 pills (50mg each).

In Pakistan it is sold by prescription under the name Tantum Capsule (50mg).

It is available in a cream and gel named Tantum Fort across Egypt by EIPICo.

It is available with prescription as a mouthwash named Novo-Benzydamine (Novopharm) in Canada.

In Mexico it is sold by prescription under the name Vantal as a mouth rinse.

In South Africa it is sold as Andolex/Andolex-C Oral Rinse, Spray and Lozenges and is manufactured by 3M Pharmaceuticals S.A. (Pty) Ltd.[3]

In Argentina it is sold as a mouthwash under the name Ernex, manufactured by Casasco.

Indications

Odontostomatology: gingivitis, stomatitis, glossitis, aphthous ulcers, dental surgery and oral ulceration due to radiation therapy.

Otorhinolaryngology: pharyngitis, tonsillitis, post-tonsillectomy, radiation or intubation mucositis.

Contraindications

There are no contraindications to the use of Benzydamine except for known hypersensitivity.

Side effects

Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur. Benzydamine may be abused recreationally.[4] In oral dosages of 500 mg to 3000 mg it is a deliriant and CNS stimulant (a cough drop has 3 mg dose), popular in Poland, Brazil and Romania. In Brazil it is very popular and widely used for recreational purposes, particularly among teenagers and as a club drug.[5] A person in a benzydamine trip may experience (because of large dopamine release) a feeling of well-being, euphoria and, in higher doses, hallucinations, paranoia, dry mouth and convulsions. The trip can last up to 8 hours, after that the user becomes tired and quiet, but sleeping is almost impossible. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic.[4]

Chemistry

File:Benzydamine synth.png

Lisciani, R (1968). "Researches on the topical activity of benzydamine". European Journal of Pharmacology. 3: 157. doi:10.1016/0014-2999(68)90069-1.

References

  1. ^ Turnbull RS. Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions. Journal of the Canadian Dental Association. 1995 Feb;61(2):127-34.
  2. ^ Material Safety Data Sheets for Difflam varieties sold in Australia
  3. ^ 3M Pharmaceuticals S.A. (Pty) Ltd
  4. ^ a b Anand JS, Glebocka ML, Korolkiewicz RP. Recreational abuse with benzydamine hydrochloride (tantum rosa). Clinical Toxicology (Philadelphia, Pa). 2007;45(2):198-9.
  5. ^ Alves L (n.d.). "Benflogin (cloridrato de benzidamina)" (in Portuguese). Brasil Escola. Retrieved on November 5, 2008.


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