Integrin alpha 6
Appearance
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.
Function
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[5]
Interactions
ITGA6 has been shown to interact with TSPAN4[6] and GIPC1.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000091409 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027111 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: ITGA6 integrin, alpha 6".
- ^ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
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: CS1 maint: unflagged free DOI (link) - ^ Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.
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: CS1 maint: unflagged free DOI (link)
Further reading
- Lipscomb EA, Mercurio AM (September 2005). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer Metastasis Reviews. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729.
External links
- CD49f+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGA6 Info with links in the Cell Migration Gateway