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Not to be confused with KIR2DL4.
CD244 molecule, natural killer cell receptor 2B4
Symbols CD244 ; 2B4; NAIL; NKR2B4; Nmrk; SLAMF4
External IDs OMIM605554 MGI109294 HomoloGene9493 GeneCards: CD244 Gene
RNA expression pattern
PBB GE CD244 220307 at tn.png
More reference expression data
Species Human Mouse
Entrez 51744 18106
Ensembl ENSG00000122223 ENSMUSG00000004709
UniProt Q9BZW8 Q07763
RefSeq (mRNA) NM_001166663 NM_018729
RefSeq (protein) NP_001160135 NP_061199
Location (UCSC) Chr 1:
160.8 – 160.83 Mb
Chr 1:
171.56 – 171.59 Mb
PubMed search [1] [2]

CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene.[1] It is also known as Natural Killer Cell Receptor 2B4[2]

This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3] CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells [4].

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