ICAM2

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Intercellular adhesion molecule 2
Protein ICAM2 PDB 1zxq.png
PDB rendering based on 1zxq.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ICAM2 ; CD102
External IDs OMIM146630 MGI96394 HomoloGene675 GeneCards: ICAM2 Gene
RNA expression pattern
PBB GE ICAM2 204683 at tn.png
PBB GE ICAM2 213620 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3384 15896
Ensembl ENSG00000108622 ENSMUSG00000001029
UniProt P13598 P35330
RefSeq (mRNA) NM_000873 NM_010494
RefSeq (protein) NP_000864 NP_034624
Location (UCSC) Chr 17:
62.08 – 62.1 Mb
Chr 11:
106.38 – 106.39 Mb
PubMed search [1] [2]

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

Protein structure[edit]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.

Protein functions[edit]

ICAM-2 molecules regulate spermatid adhesion on Sertori cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis.[1]

This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.[2]

Interactions[edit]

ICAM2 has been shown to interact with EZR.[3]

See also[edit]

References[edit]

  1. ^ Xiao, X.; Mruk, D. D.; Cheng, C. Y. (2013). "Intercellular adhesion molecules (ICAMs) and spermatogenesis". Human Reproduction Update 19 (2): 167–186. doi:10.1093/humupd/dms049. PMC 3576004. PMID 23287428.  edit
  2. ^ "Entrez Gene: ICAM2 intercellular adhesion molecule 2". 
  3. ^ Heiska, L; Alfthan K; Grönholm M; Vilja P; Vaheri A; Carpén O (Aug 1998). "Association of ezrin with intercellular adhesion molecule-1 and −2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". J. Biol. Chem. (UNITED STATES) 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. ISSN 0021-9258. PMID 9705328. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.