IL18RAP

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Interleukin 18 receptor accessory protein
Identifiers
Symbols IL18RAP ; ACPL; CD218b; CDw218b; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB
External IDs OMIM604509 MGI1338888 HomoloGene2859 GeneCards: IL18RAP Gene
RNA expression pattern
PBB GE IL18RAP 207072 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8807 16174
Ensembl ENSG00000115607 ENSMUSG00000026068
UniProt O95256 Q9Z2B1
RefSeq (mRNA) NM_003853 NM_010553
RefSeq (protein) NP_003844 NP_034683
Location (UCSC) Chr 2:
103.04 – 103.07 Mb
Chr 1:
40.52 – 40.55 Mb
PubMed search [1] [2]

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.[1][2]

Function[edit]

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.[1]

Disease association[edit]

Variants at IL18RAP have been linked to susceptibility to Coeliac disease.[3]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: IL18RAP interleukin 18 receptor accessory protein". 
  2. ^ Born TL, Thomassen E, Bird TA, Sims JE (November 1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. doi:10.1074/jbc.273.45.29445. PMID 9792649. 
  3. ^ Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA (April 2008). "Novel celiac disease genetic determinants related to the immune response". Nat. Genet. 40 (4): 395–402. doi:10.1038/ng.102. PMC 2673512. PMID 18311140. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.